9K6H
Structure of human LINE-1 ORF2p with endogenous DNA and RNA/cDNA hybrid bound to dNTP and Mn2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LINE-1 retrotransposable element ORF2 protein | polymer | 1274 | 149153.1 | 1 | UniProt (O00370) | Homo sapiens (human) | ORF2p |
| 2 | B (B) | Genomic DNA (top strand) | polymer | 20 | 6027.0 | 1 | Trichoplusia ni | ||
| 3 | C (C) | Genomic DNA (bottom strand) | polymer | 12 | 3605.4 | 1 | Trichoplusia ni | ||
| 4 | D (D) | Complementary DNA | polymer | 10 | 3087.1 | 1 | Trichoplusia ni | ||
| 5 | E (E) | Template RNA | polymer | 12 | 3629.0 | 1 | Trichoplusia ni | ||
| 6 | F (A) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 1 | Chemie (DTP) | |||
| 7 | G (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | H (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) |
Sequence modifications
A: 2 - 1275 (UniProt: O00370)
| PDB | External Database | Details |
|---|---|---|
| Thr 5 | Asn 5 | variant |
| Ile 15 | Val 15 | variant |
| Ala 21 | Pro 21 | variant |
| Thr 152 | Ile 152 | variant |
| Ala 175 | Thr 175 | variant |
| Met 595 | Val 595 | variant |
| Thr 625 | Met 625 | variant |
| Phe 627 | Leu 627 | variant |
| Thr 744 | Asn 744 | variant |
| Glu 795 | Asp 795 | variant |
| Phe 932 | Leu 932 | variant |
| Leu 1141 | Val 1141 | variant |
| Asn 1182 | Lys 1182 | variant |
| Glu 1183 | Asp 1183 | variant |
| Lys 1212 | Asn 1212 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 165501.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 611.5 | |
| All* | Total formula weight | 166113.1 |
