9K6H
Structure of human LINE-1 ORF2p with endogenous DNA and RNA/cDNA hybrid bound to dNTP and Mn2+
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 275 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Domain: {"description":"DUF1725"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 179 |
| Details | Region: {"description":"Carboxy-terminal segment; binds RNA","evidences":[{"source":"PubMed","id":"24251107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Motif: {"description":"FADD motif","evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
