9K2W
Cryo-EM structure of USP7:DNMT1 complex; closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 1107 | 128884.2 | 1 | UniProt (Q93009) Pfam (PF22486) Pfam (PF00443) Pfam (PF12436) Pfam (PF14533) | Homo sapiens (human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | B (B) | DNA (cytosine-5)-methyltransferase 1 | polymer | 1271 | 143559.5 | 1 | UniProt (P26358) Pfam (PF12047) Pfam (PF02008) Pfam (PF01426) Pfam (PF00145) | Homo sapiens (human) | Dnmt1,CXXC-type zinc finger protein 9,DNA methyltransferase HsaI,DNA MTase HsaI,M.HsaI,MCMT |
| 3 | C, D (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 1 - 1102 (UniProt: Q93009)
B: 351 - 1616 (UniProt: P26358)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Pro 348 | - | expression tag |
| Thr 349 | - | expression tag |
| Thr 350 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 272443.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 272574.6 |
