9K1S

Crystal structure of human granzyme A in complex with GSDMB-C domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Granzyme A	polymer	242	26926.2	2	UniProt (P12544) Pfam (PF00089)	Homo sapiens (human)	CTL tryptase,Cytotoxic T-lymphocyte proteinase 1,Fragmentin-1,Granzyme-1,Hanukkah factor,H factor,HF
2	C, D (C, D)	Isoform 4 of Gasdermin-B	polymer	176	19522.1	2	UniProt (Q8TAX9) Pfam (PF17708)	Homo sapiens (human)	Gasdermin-like protein
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)

Sequence modifications

A, B: 29 - 262 (UniProt: P12544)

PDB	External Database	Details
Thr 121	Met 121	variant
Leu 263	-	expression tag
Glu 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag

C, D: 245 - 416 (UniProt: Q8TAX9)

PDB	External Database	Details
Ser 241	-	expression tag
Gly 242	-	expression tag
Arg 243	-	expression tag
Pro 244	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	92896.6
Branched	Number of molecules	2
	Total formula weight	848.8
All*	Total formula weight	93745.4

*Water molecules are not included.