9K1S

Crystal structure of human granzyme A in complex with GSDMB-C domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001772	cellular_component	immunological synapse
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006915	biological_process	apoptotic process
A	0006955	biological_process	immune response
A	0008236	molecular_function	serine-type peptidase activity
A	0030163	biological_process	protein catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0044194	cellular_component	cytolytic granule
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptotic inflammatory response
A	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
A	1902483	biological_process	cytotoxic T cell pyroptotic cell death
B	0001772	cellular_component	immunological synapse
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006915	biological_process	apoptotic process
B	0006955	biological_process	immune response
B	0008236	molecular_function	serine-type peptidase activity
B	0030163	biological_process	protein catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0044194	cellular_component	cytolytic granule
B	0051604	biological_process	protein maturation
B	0070269	biological_process	pyroptotic inflammatory response
B	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
B	1902483	biological_process	cytotoxic T cell pyroptotic cell death

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU65-CYS70

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGSPLL

Chain	Residue	Details
A	ASP206-LEU217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	460
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12819769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12819770","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12819769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12819770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32299851","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34022140","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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