9JQ6
Cryo-EM structure of BTN2A1 in complex with antagonist antibody TH002
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (E, F) | Butyrophilin subfamily 2 member A1 | polymer | 532 | 60015.3 | 2 | UniProt (Q7KYR7) Pfam (PF07686) Pfam (PF22705) Pfam (PF13765) Pfam (PF00622) | Homo sapiens (human) | |
| 2 | C, E (H, J) | BTN2A1 antagonist antibody TH002-Fab heavy chain | polymer | 231 | 24961.3 | 2 | Mus musculus | ||
| 3 | D, F (I, K) | BTN2A1 antagonist antibody TH002-Fab light chain | polymer | 218 | 23813.0 | 2 | Mus musculus | ||
| 4 | G, H, I (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J, K, L, M, N... (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
E, F: 1 - 499 (UniProt: Q7KYR7)
| PDB | External Database | Details |
|---|---|---|
| Gly 500 | - | expression tag |
| Gly 501 | - | expression tag |
| Gly 502 | - | expression tag |
| Gly 503 | - | expression tag |
| Ser 504 | - | expression tag |
| Trp 505 | - | expression tag |
| Ser 506 | - | expression tag |
| His 507 | - | expression tag |
| Pro 508 | - | expression tag |
| Gln 509 | - | expression tag |
| Phe 510 | - | expression tag |
| Glu 511 | - | expression tag |
| Lys 512 | - | expression tag |
| Gly 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Ser 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Gly 521 | - | expression tag |
| Gly 522 | - | expression tag |
| Ser 523 | - | expression tag |
| Ala 524 | - | expression tag |
| Trp 525 | - | expression tag |
| Ser 526 | - | expression tag |
| His 527 | - | expression tag |
| Pro 528 | - | expression tag |
| Gln 529 | - | expression tag |
| Phe 530 | - | expression tag |
| Glu 531 | - | expression tag |
| Lys 532 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 217579.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1548.5 | |
| All* | Total formula weight | 220400.9 |
