9JFK
Cryo-EM structure of [Pen5]-urotensin (4-11)-bounded human Urotensin receptor (UTS2R)-Gq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (B) | G subunit q (gi2-mini-gq chimeric) | polymer | 246 | 28084.8 | 1 | Homo sapiens (human) | ||
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nano body 35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 5 | E (R) | Urotensin-2 receptor | polymer | 347 | 37857.5 | 1 | UniProt (Q9UKP6) Pfam (PF00001) | Homo sapiens (human) | UR-2-R,G-protein coupled receptor 14,Urotensin II receptor,UR-II-R |
| 6 | F (C) | ASP-LE1-PHE-TRP-LYS-TYR-CYS-VAL | polymer | 8 | 1092.3 | 1 | synthetic construct | ||
| 7 | G, H (R) | GLYCOCHENODEOXYCHOLIC ACID | non-polymer | 449.6 | 2 | Chemie (CHO) |
Sequence modifications
A: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 126565.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 899.2 | |
| All* | Total formula weight | 127464.7 |
