9JFK
Cryo-EM structure of [Pen5]-urotensin (4-11)-bounded human Urotensin receptor (UTS2R)-Gq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (B) | G subunit q (gi2-mini-gq chimeric) | polymer | 246 | 28084.8 | 1 | Homo sapiens (human) | ||
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nano body 35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 5 | E (R) | Urotensin-2 receptor | polymer | 347 | 37857.5 | 1 | UniProt (Q9UKP6) Pfam (PF00001) | Homo sapiens (human) | UR-2-R,G-protein coupled receptor 14,Urotensin II receptor,UR-II-R |
| 6 | F (C) | ASP-LE1-PHE-TRP-LYS-TYR-CYS-VAL | polymer | 8 | 1092.3 | 1 | synthetic construct | ||
| 7 | G, H (R) | GLYCOCHENODEOXYCHOLIC ACID | non-polymer | 449.6 | 2 | Chemie (CHO) PubChem (17753896) PubChem (22808456) PubChem (22833540) PubChem (93353) PubChem (16213700) PubChem (440686) PubChem (22808055) PubChem (44312819) PubChem (45052109) PubChem (46839357) PubChem (49874127) PubChem (53391261) PubChem (56606329) PubChem (57696971) PubChem (58104997) PubChem (53477907) PubChem (70420975) PubChem (76329458) PubChem (86310768) PubChem (86312248) PubChem (86328252) PubChem (86331070) PubChem (12544) PubChem (27929) PubChem (10095257) PubChem (86312246) PubChem (86331068) PubChem (86310766) PubChem (10389035) PubChem (10994028) PubChem (94029808) PubChem (90474429) PubChem (12310284) PubChem (12310285) PubChem (12310287) PubChem (12310288) PubChem (91746178) PubChem (91798922) PubChem (99564958) PubChem (99564959) PubChem (99566017) PubChem (92450270) PubChem (97629473) PubChem (99564957) PubChem (124335016) PubChem (124784355) PubChem (124899320) PubChem (9933432) PubChem (118554507) PubChem (134692575) PubChem (134555903) PubChem (122361926) PubChem (12310291) PubChem (124350391) PubChem (124350392) PubChem (124422684) PubChem (12310290) PubChem (124899321) PubChem (124899323) PubChem (124902784) PubChem (124902786) PubChem (124902792) PubChem (124905412) PubChem (126963422) PubChem (126968461) PubChem (129317599) PubChem (131632351) PubChem (133109218) PubChem (133612048) PubChem (133688432) PubChem (137349097) PubChem (139024238) PubChem (139291853) PubChem (139291854) PubChem (142492682) PubChem (159623905) PubChem (163025202) PubChem (163198935) PubChem (163337735) PubChem (175271619) |
Sequence modifications
A: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 126565.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 899.2 | |
| All* | Total formula weight | 127464.7 |
