9JEJ

Crystal structure of human EP300 KIX domain (L644C mutant)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Histone acetyltransferase p300	polymer	101	12079.8	3	UniProt (Q09472) Pfam (PF02172)	Homo sapiens (human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300
2	D (C)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	E, F, G (A, B, C)	water	water		18.0	5	Chemie (HOH)

Sequence modifications

A, B, C: 566 - 652 (UniProt: Q09472)

PDB	External Database	Details
Met 552	-	initiating methionine
Arg 553	-	expression tag
Gly 554	-	expression tag
Ser 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag
Gly 562	-	expression tag
Met 563	-	expression tag
Ala 564	-	expression tag
Ser 565	-	expression tag
Cys 644	Leu 644	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	36239.4
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	36304.8

*Water molecules are not included.