9JCX
Crystal structure of the HCoV-HKU1 RBD and TMPRSS2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protease serine 2 non-catalytic chain | polymer | 146 | 16054.7 | 1 | UniProt (O15393) Pfam (PF15494) | Homo sapiens (human) | |
| 2 | B (C) | Transmembrane protease serine 2 catalytic chain | polymer | 249 | 27840.7 | 1 | UniProt (O15393) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (B) | Spike protein S1 | polymer | 308 | 34275.0 | 1 | UniProt (Q5MQD0) | Human coronavirus HKU1 (isolate N1) | |
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F, G (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | H, I, J (A, C, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 109 - 254 (UniProt: O15393)
C: 256 - 492 (UniProt: O15393)
B: 323 - 609 (UniProt: Q5MQD0)
| PDB | External Database | Details |
|---|---|---|
| Asp 250 | Ser 250 | engineered mutation |
| Asp 251 | Ser 251 | engineered mutation |
| Asp 252 | Arg 252 | engineered mutation |
| Asp 253 | Gln 253 | engineered mutation |
| Lys 254 | Ser 254 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 441 | Ser 441 | engineered mutation |
| Glu 493 | - | expression tag |
| Phe 494 | - | expression tag |
| Val 495 | - | expression tag |
| Glu 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 610 | - | expression tag |
| Gly 611 | - | expression tag |
| Leu 612 | - | expression tag |
| Glu 613 | - | expression tag |
| Val 614 | - | expression tag |
| Leu 615 | - | expression tag |
| Phe 616 | - | expression tag |
| Gln 617 | - | expression tag |
| Gly 618 | - | expression tag |
| Pro 619 | - | expression tag |
| Gly 620 | - | expression tag |
| Gly 621 | - | expression tag |
| Ser 622 | - | expression tag |
| His 623 | - | expression tag |
| His 624 | - | expression tag |
| His 625 | - | expression tag |
| His 626 | - | expression tag |
| His 627 | - | expression tag |
| His 628 | - | expression tag |
| His 629 | - | expression tag |
| His 630 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 78170.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 703.7 | |
| All* | Total formula weight | 78874.1 |
