9JBV

Structure of Engineered Coagulation Factor VIII with Enhanced Secretion and Coagulation Potential

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Coagulation factor VIII	polymer	1457	167452.5	1	UniProt (P00451) Pfam (PF07732) Pfam (PF07731) Pfam (PF00754)	Homo sapiens (human)	Antihemophilic factor,AHF,Procoagulant component

Sequence modifications

A: 1 - 764 (UniProt: P00451)

PDB	External Database	Details
Pro 15	Arg 15	conflict
His 44	Pro 44	conflict
Thr 47	Ala 47	conflict
Pro 171	Leu 171	conflict
Asn 232	Lys 232	conflict
Thr 236	Met 236	conflict
Gln 247	Trp 247	conflict
Pro 386	Ser 386	conflict
Leu 429	Gln 429	conflict
His 506	Tyr 506	conflict
Gly 508	Arg 508	conflict
Met 520	Phe 520	conflict
Leu 558	Met 558	conflict
Met 585	Ile 585	conflict
Pro 622	Leu 622	conflict
Val 661	Ile 661	conflict
Pro 746	Ser 746	conflict
Val 755	Ala 755	conflict

A: 765 - 1457 (UniProt: P00451)

PDB	External Database	Details
Pro 782	Ser 1676	conflict
Glu 784	Gln 1678	conflict
Lys 786	Glu 1680	conflict
Phe 793	Ile 1687	conflict
Gly 806	Asp 1700	conflict
Lys 901	Arg 1795	conflict
Arg 984	His 1878	conflict
Val 1118	Ala 2012	conflict
Gln 1132	His 2026	conflict
Lys 1144	Asn 2038	conflict
Met 1210	Lys 2104	conflict
Leu 1321	Phe 2215	conflict
Gln 1332	Lys 2226	conflict
Leu 1400	Phe 2294	conflict
Ala 1421	Ser 2315	conflict
Ala 1439	Val 2333	conflict
His 1441	Gln 2335	conflict
Leu 1446	Met 2340	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	167452.5
All*	Total formula weight	167452.5

*Water molecules are not included.