9JBV
Structure of Engineered Coagulation Factor VIII with Enhanced Secretion and Coagulation Potential
Functional Information from PROSITE/UniProt
| site_id | PS00079 |
| Number of Residues | 21 |
| Details | MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshQhDGMeayV |
| Chain | Residue | Details |
| A | GLY323-VAL343 | |
| A | GLY705-LEU725 | |
| A | GLY1119-PHE1139 |
| site_id | PS01285 |
| Number of Residues | 28 |
| Details | FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgImTQG |
| Chain | Residue | Details |
| A | ALA1186-GLY1213 | |
| A | ALA1343-GLY1372 |
| site_id | PS01286 |
| Number of Residues | 17 |
| Details | FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC |
| Chain | Residue | Details |
| A | PRO1278-CYS1294 | |
| A | PRO1435-CYS1451 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 142 |
| Details | Domain: {"description":"Plastocyanin-like 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 331 |
| Details | Domain: {"description":"F5/8 type A 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 174 |
| Details | Domain: {"description":"Plastocyanin-like 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 147 |
| Details | Domain: {"description":"Plastocyanin-like 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 153 |
| Details | Domain: {"description":"Plastocyanin-like 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 148 |
| Details | Domain: {"description":"F5/8 type C 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 152 |
| Details | Domain: {"description":"F5/8 type C 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
