9JBE
Cryo-EM structure of the human LYCHOS in complex with cholesterol and cholesteryl hemisuccinate in the contracted state
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal cholesterol signaling protein | polymer | 878 | 98033.8 | 2 | UniProt (Q7Z3F1) Pfam (PF03547) Pfam (PF00610) | Homo sapiens (human) | LYCHOS,G-protein coupled receptor PGR22 |
| 2 | C, D, M, N (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 3 | E, F, J, L, O... (A, B) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 6 | Chemie (3PE) | |||
| 4 | G (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 5 | H, Q (A, B) | [(2~{S})-1-[[(2~{S})-2-[(~{Z})-octadec-9-enoyl]oxy-3-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-3-oxidanyl-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 775.0 | 2 | Chemie (A1L34) | |||
| 6 | I, K (A, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) |
Sequence modifications
A, B: 1 - 870 (UniProt: Q7Z3F1)
| PDB | External Database | Details |
|---|---|---|
| Ser 871 | - | expression tag |
| Arg 872 | - | expression tag |
| Glu 873 | - | expression tag |
| Asn 874 | - | expression tag |
| Leu 875 | - | expression tag |
| Tyr 876 | - | expression tag |
| Phe 877 | - | expression tag |
| Gln 878 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 196067.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 9952.3 | |
| All* | Total formula weight | 206020.0 |
