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9JBE

Cryo-EM structure of the human LYCHOS in complex with cholesterol and cholesteryl hemisuccinate in the contracted state

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Lysosomal cholesterol signaling proteinpolymer87898033.82UniProt (Q7Z3F1)Homo sapiens (human)LYCHOS,G-protein coupled receptor PGR22
2C, D, M, N
(A, B)
CHOLESTEROL HEMISUCCINATEnon-polymer486.74Chemie (Y01)
3E, F, J, L, O...
(A, B)
1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.16Chemie (3PE)
4G
(A)
CHOLESTEROLnon-polymer386.71Chemie (CLR)
5H, Q
(A, B)
[(2~{S})-1-[[(2~{S})-2-[(~{Z})-octadec-9-enoyl]oxy-3-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-3-oxidanyl-propan-2-yl] (~{Z})-octadec-9-enoatenon-polymer775.02Chemie (A1L34)
6I, K
(A, B)
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.12Chemie (PC1)
Sequence modifications
A, B: 1 - 870 (UniProt: Q7Z3F1)
PDBExternal DatabaseDetails
Ser 871-expression tag
Arg 872-expression tag
Glu 873-expression tag
Asn 874-expression tag
Leu 875-expression tag
Tyr 876-expression tag
Phe 877-expression tag
Gln 878-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight196067.6
Non-Polymers*Number of molecules15
Total formula weight9952.3
All*Total formula weight206020.0
*Water molecules are not included.

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PDB entries from 2025-07-16

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