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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9JBE

Cryo-EM structure of the human LYCHOS in complex with cholesterol and cholesteryl hemisuccinate in the contracted state

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues176
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues170
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsTransmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues78
DetailsDomain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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