9IZX
Cryo-EM structure of ALDH6A1-G446R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial | polymer | 509 | 55473.6 | 4 | UniProt (Q02252) Pfam (PF00171) | Homo sapiens (human) | MMSDH,Aldehyde dehydrogenase family 6 member A1,Malonate-semialdehyde dehydrogenase [acylating] |
Sequence modifications
A, B, C, D: 2 - 503 (UniProt: Q02252)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Arg 414 | Gly 446 | engineered mutation |
| Glu 504 | - | expression tag |
| Asn 505 | - | expression tag |
| Leu 506 | - | expression tag |
| Tyr 507 | - | expression tag |
| Phe 508 | - | expression tag |
| Gln 509 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 221894.5 | |
| All* | Total formula weight | 221894.5 |
