9IZX

Cryo-EM structure of ALDH6A1-G446R

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006210	biological_process	thymine catabolic process
A	0006573	biological_process	valine metabolic process
A	0006574	biological_process	L-valine catabolic process
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019859	biological_process	thymine metabolic process
B	0003723	molecular_function	RNA binding
B	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006210	biological_process	thymine catabolic process
B	0006573	biological_process	valine metabolic process
B	0006574	biological_process	L-valine catabolic process
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019859	biological_process	thymine metabolic process
C	0003723	molecular_function	RNA binding
C	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006210	biological_process	thymine catabolic process
C	0006573	biological_process	valine metabolic process
C	0006574	biological_process	L-valine catabolic process
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019859	biological_process	thymine metabolic process
D	0003723	molecular_function	RNA binding
D	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006210	biological_process	thymine catabolic process
D	0006573	biological_process	valine metabolic process
D	0006574	biological_process	L-valine catabolic process
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019859	biological_process	thymine metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FgAAGQRCMALS

Chain	Residue	Details
A	PHE278-SER289

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P42412","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9EQ20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9EQ20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9EQ20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---