9IQX

Cryo-EM structure of the human TRPV4-RhoA in complex with AH001

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, D, A, B)	Transient receptor potential cation channel subfamily V member 4	polymer	640	73038.7	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	E, F (E, F)	Transforming protein RhoA	polymer	193	21799.2	2	UniProt (P61586) Pfam (PF00071)	Homo sapiens (human)	Rho cDNA clone 12,h12
3	G, I (C, A)	O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine	non-polymer		792.1	2	Chemie (P5S)
4	H, J (C, A)	(1~{R})-1-(3-ethylphenyl)ethane-1,2-diol	non-polymer		166.2	2	Chemie (U6L)
5	K, M (E, F)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
6	L, N (E, F)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	335753.2
Non-Polymers*	Number of molecules	8
	Total formula weight	2851.6
All*	Total formula weight	338604.8

*Water molecules are not included.