9IML
Sertraline enhances the deubiquitinase activity of USP7 by binding to its switching loop region
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 353 | 41004.3 | 4 | UniProt (Q93009) Pfam (PF00443) | Homo sapiens (human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | B, D, F, H (B, D, F, H) | Ubiquitin | polymer | 75 | 8519.8 | 4 | UniProt (P62979) Pfam (PF00240) UniProt (by SIFTS) (P0CG48) | Homo sapiens (human) | |
| 3 | I (C) | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine | non-polymer | 458.6 | 1 | Chemie (XB7) | |||
| 4 | J, K, L, M, N... (A, B, C, D, E...) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 198096.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.6 | |
| All* | Total formula weight | 198555.0 |
