9IMA

Cryo-EM structure for the GPRC5D complexed with Talquetamab Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Talquetamab Fab (anti-GPRC5D) Heavy chain	polymer	233	25137.2	1		Mus musculus
2	B (D)	Talquetamab Fab (anti-GPRC5D) Light chain	polymer	214	23666.2	1		Mus musculus
3	C, D (B, A)	G-protein coupled receptor family C group 5 member D	polymer	352	39540.0	2	UniProt (Q9NZD1) Pfam (PF00003)	Homo sapiens (human)
4	E, F, G, H, I... (B, A)	CHOLESTEROL	non-polymer		386.7	6	Chemie (CLR)

Sequence modifications

B, A: 1 - 308 (UniProt: Q9NZD1)

PDB	External Database	Details
Met -2	-	initiating methionine
Val -1	-	expression tag
Asp 0	-	expression tag
Ser 309	-	expression tag
Gly 310	-	expression tag
Ser 311	-	expression tag
Gly 312	-	expression tag
Ser 313	-	expression tag
Gly 314	-	expression tag
Arg 315	-	expression tag
Gly 316	-	expression tag
Arg 317	-	expression tag
Gly 318	-	expression tag
Gly 319	-	expression tag
Ser 320	-	expression tag
Glu 321	-	expression tag
Asn 322	-	expression tag
Leu 323	-	expression tag
Tyr 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Gly 328	-	expression tag
Ser 329	-	expression tag
Gly 330	-	expression tag
Ser 331	-	expression tag
Gly 332	-	expression tag
Gly 333	-	expression tag
Asp 334	-	expression tag
Tyr 335	-	expression tag
Lys 336	-	expression tag
Asp 337	-	expression tag
Asp 338	-	expression tag
Asp 339	-	expression tag
Asp 340	-	expression tag
Lys 341	-	expression tag
Asp 342	-	expression tag
Tyr 343	-	expression tag
Lys 344	-	expression tag
Asp 345	-	expression tag
Asp 346	-	expression tag
Asp 347	-	expression tag
Asp 348	-	expression tag
Lys 349	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127883.5
Non-Polymers*	Number of molecules	6
	Total formula weight	2319.9
All*	Total formula weight	130203.4

*Water molecules are not included.