9IMA
Cryo-EM structure for the GPRC5D complexed with Talquetamab Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Talquetamab Fab (anti-GPRC5D) Heavy chain | polymer | 233 | 25137.2 | 1 | Mus musculus | ||
| 2 | B (D) | Talquetamab Fab (anti-GPRC5D) Light chain | polymer | 214 | 23666.2 | 1 | Mus musculus | ||
| 3 | C, D (B, A) | G-protein coupled receptor family C group 5 member D | polymer | 352 | 39540.0 | 2 | UniProt (Q9NZD1) Pfam (PF00003) | Homo sapiens (human) | |
| 4 | E, F, G, H, I... (B, A) | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) |
Sequence modifications
B, A: 1 - 308 (UniProt: Q9NZD1)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Ser 309 | - | expression tag |
| Gly 310 | - | expression tag |
| Ser 311 | - | expression tag |
| Gly 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Gly 314 | - | expression tag |
| Arg 315 | - | expression tag |
| Gly 316 | - | expression tag |
| Arg 317 | - | expression tag |
| Gly 318 | - | expression tag |
| Gly 319 | - | expression tag |
| Ser 320 | - | expression tag |
| Glu 321 | - | expression tag |
| Asn 322 | - | expression tag |
| Leu 323 | - | expression tag |
| Tyr 324 | - | expression tag |
| Phe 325 | - | expression tag |
| Gln 326 | - | expression tag |
| Gly 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Ser 329 | - | expression tag |
| Gly 330 | - | expression tag |
| Ser 331 | - | expression tag |
| Gly 332 | - | expression tag |
| Gly 333 | - | expression tag |
| Asp 334 | - | expression tag |
| Tyr 335 | - | expression tag |
| Lys 336 | - | expression tag |
| Asp 337 | - | expression tag |
| Asp 338 | - | expression tag |
| Asp 339 | - | expression tag |
| Asp 340 | - | expression tag |
| Lys 341 | - | expression tag |
| Asp 342 | - | expression tag |
| Tyr 343 | - | expression tag |
| Lys 344 | - | expression tag |
| Asp 345 | - | expression tag |
| Asp 346 | - | expression tag |
| Asp 347 | - | expression tag |
| Asp 348 | - | expression tag |
| Lys 349 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127883.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2319.9 | |
| All* | Total formula weight | 130203.4 |
