9IKQ
Crystal structure of OPTN LZD in complex with GTP-bound Rab8a(Q67L)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Ras-related protein Rab-8A | polymer | 181 | 20766.9 | 2 | UniProt (P61006) Pfam (PF00071) | Homo sapiens (human) | Oncogene c-mel |
| 2 | B, C (C, D) | Optineurin | polymer | 38 | 4326.9 | 2 | UniProt (Q96CV9) | Homo sapiens (human) | E3-14.7K-interacting protein,FIP-2,Huntingtin yeast partner L,Huntingtin-interacting protein 7,HIP-7,Huntingtin-interacting protein L,NEMO-related protein,Optic neuropathy-inducing protein,Transcription factor IIIA-interacting protein,TFIIIA-IntP |
| 3 | E, L (A, B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | F, Q (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, H, I, J, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | M, N, O, P (B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 7 | S, T, U, V (A, C, D, B) | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 181 (UniProt: P61006)
| PDB | External Database | Details |
|---|---|---|
| Leu 67 | Gln 67 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 50187.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1835.8 | |
| All* | Total formula weight | 52023.4 |
