9I7X

Cryo-EM structure of human IL-36gamma in complex with the IL-36R and IL-1RAcP ectodomains

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-1 receptor accessory protein	polymer	351	40339.9	1	UniProt (Q9NPH3)	Homo sapiens (human)	IL-1 receptor accessory protein,IL-1RAcP,Interleukin-1 receptor 3,IL-1R-3,IL-1R3
2	B (B)	Interleukin-36 gamma	polymer	152	17045.4	1	UniProt (Q9NZH8)	Homo sapiens (human)	IL-1-related protein 2,IL-1RP2,Interleukin-1 epsilon,IL-1 epsilon,Interleukin-1 family member 9,IL-1F9,Interleukin-1 homolog 1,IL-1H1
3	C (C)	Interleukin-1 receptor-like 2	polymer	320	36407.2	1	UniProt (Q9HB29)	Homo sapiens (human)	IL-36 receptor,IL-36R,Interleukin-1 receptor-related protein 2,IL-1Rrp2,IL1R-rp2
4	D (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E, F, G, H, I... (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG) PubChem (24139)

Sequence modifications

A: 21 - 367 (UniProt: Q9NPH3)

PDB	External Database	Details
Asp 368	-	expression tag
Glu 369	-	expression tag
Val 370	-	expression tag
Asp 371	-	expression tag

C: 20 - 335 (UniProt: Q9HB29)

PDB	External Database	Details
Ser 154	Cys 154	engineered mutation
Ser 262	Cys 262	engineered mutation
Asp 336	-	expression tag
Glu 337	-	expression tag
Val 338	-	expression tag
Asp 339	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	93792.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	9
	Total formula weight	1990.9
All*	Total formula weight	96207.7

*Water molecules are not included.