9HZ5
Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Protein transport protein Sec61 subunit alpha | polymer | 412 | 45829.0 | 1 | Pfam (PF10559) Pfam (PF00344) UniProt (by SIFTS) (F7G1S7) | Ovis aries | |
| 2 | B (A) | Protein transport protein Sec61 subunit gamma | polymer | 59 | 6722.1 | 1 | Pfam (PF00584) UniProt (by SIFTS) (A0A6I8MX59) | Ovis aries | |
| 3 | C (C) | Protein transport protein Sec61 subunit beta | polymer | 20 | 2316.9 | 1 | Pfam (PF03911) UniProt (by SIFTS) (R0L5M3) | Ovis aries | |
| 4 | D (B) | 4-{(3S)-9-(cyclohexylmethyl)-5-[(3R,5R)-4-(3-fluoro-5-methoxyphenyl)-3,5-dimethylpiperazine-1-sulfonyl]-3-methyl-1,5,9-triazacyclododecane-1-sulfonyl}-N,N-dimethylaniline | non-polymer | 765.1 | 1 | Chemie (A1A2B) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 54868.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 765.1 | |
| All* | Total formula weight | 55633.1 |
