9HZ3

PCSK9 AZD0780 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proprotein convertase subtilisin/kexin type 9	polymer	152	17035.5	1	UniProt (Q8NBP7) Pfam (PF05922)	Homo sapiens (human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	B (B)	Proprotein convertase subtilisin/kexin type 9	polymer	553	59124.5	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463)	Homo sapiens (human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
3	C (B)	1-[6-[[(1~{S},3~{S})-3-[[5-[bis(fluoranyl)methoxy]pyrimidin-2-yl]amino]cyclopentyl]amino]pyridin-3-yl]pyridin-2-one	non-polymer		414.4	1	Chemie (A1IYR)
4	D, E (A, B)	water	water		18.0	443	Chemie (HOH)

Sequence modifications

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ile 474	Val 474	variant
Glu 670	Gly 670	variant
Glu 693	-	expression tag
Asn 694	-	expression tag
Leu 695	-	expression tag
Tyr 696	-	expression tag
Phe 697	-	expression tag
Gln 698	-	expression tag
Gly 699	-	expression tag
His 700	-	expression tag
His 701	-	expression tag
His 702	-	expression tag
His 703	-	expression tag
His 704	-	expression tag
His 705	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76160.0
Non-Polymers*	Number of molecules	1
	Total formula weight	414.4
All*	Total formula weight	76574.4

*Water molecules are not included.