9HZ3

PCSK9 AZD0780 complex

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	MAX IV BEAMLINE BioMAX
Synchrotron site	MAX IV
Beamline	BioMAX
Temperature [K]	100
Detector technology	PIXEL
Collection date	2024-05-23
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.97625
Spacegroup name	P 21 21 21
Unit cell lengths	62.974, 70.724, 149.782
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	74.890 - 1.432
R-factor	0.1938
Rwork	0.193
R-free	0.21290
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.011
RMSD bond angle	1.140
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	BUSTER (2.11.8)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	74.891	4.297
High resolution limit [Å]	1.432	1.432
Number of reflections	98008	4900
<I/σ(I)>	10.1
Completeness [%]	79.3
Redundancy	6.7
CC(1/2)	0.998	0.996

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION		293	25 mM HEPES pH 7.5 300 mM NaCl 5% glycerol