9HYN
CRYSTAL STRUCTURE OF THE SMARCA2-VCB-COMPLEX WITH PROTAC P1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B, E (B, E) | Elongin-C | polymer | 103 | 11645.5 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C, F (C, F) | von Hippel-Lindau disease tumor suppressor | polymer | 168 | 19402.1 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | G, H (G, H) | Isoform Short of Probable global transcription activator SNF2L2 | polymer | 129 | 15082.4 | 2 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 5 | I, J (C, F) | (2~{S},4~{R})-~{N}-[[2-[2-[2-[4-[(6-bromanyl-3-methyl-5-oxidanylidene-4~{H}-imidazo[1,2-a]quinazolin-2-yl)methyl]piperazin-1-yl]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 980.0 | 2 | Chemie (A1IYO) | |||
| 6 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
B, E: 17 - 112 (UniProt: Q15369)
C, F: 54 - 212 (UniProt: P40337)
G, H: 1373 - 1493 (UniProt: P51531)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| Leu 113 | - | expression tag |
| Glu 114 | - | expression tag |
| Leu 115 | - | expression tag |
| Leu 116 | - | expression tag |
| Met 117 | - | expression tag |
| Ala 118 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| Thr 213 | - | expression tag |
| Gln 214 | - | expression tag |
| Glu 215 | - | expression tag |
| Arg 216 | - | expression tag |
| Ile 217 | - | expression tag |
| Ala 218 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 1371 | - | expression tag |
| Met 1372 | - | expression tag |
| Lys 1494 | - | expression tag |
| Ser 1495 | - | expression tag |
| Ala 1496 | - | expression tag |
| Arg 1497 | - | expression tag |
| Gln 1498 | - | expression tag |
| Lys 1499 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 115756.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1960.0 | |
| All* | Total formula weight | 117716.6 |
