9HVQ
Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed RNA polymerase subunit | polymer | 1970 | 217450.1 | 1 | UniProt (A0A8D1DPV6) Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) | Sus scrofa domesticus (domestic pig) | |
| 2 | B (B) | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (A0A0B8RVL1) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) | Sus scrofa domesticus (domestic pig) | |
| 3 | C (C) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 275 | 31439.1 | 1 | UniProt (I3LCH3) Pfam (PF01193) Pfam (PF01000) | Sus scrofa domesticus (domestic pig) | RNA polymerase II subunit C |
| 4 | D (D) | RNA polymerase II subunit D | polymer | 142 | 16331.3 | 1 | UniProt (A0A4X1VM56) Pfam (PF03874) | Sus scrofa domesticus (domestic pig) | |
| 5 | E (E) | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (I3LSI7) Pfam (PF03871) Pfam (PF01191) | Sus scrofa domesticus (domestic pig) | RPB5 homolog |
| 6 | F (F) | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14477.0 | 1 | UniProt (A0A4X1VEK9) Pfam (PF01192) | Sus scrofa domesticus (domestic pig) | DNA-directed RNA polymerase II subunit F,RPB6 homolog |
| 7 | G (G) | DNA-directed RNA polymerase subunit | polymer | 172 | 19314.3 | 1 | UniProt (A0A4X1VKG7) Pfam (PF03876) Pfam (PF00575) | Sus scrofa domesticus (domestic pig) | |
| 8 | H (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (I3LCB2) Pfam (PF03870) | Sus scrofa domesticus (domestic pig) | |
| 9 | I (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) | Sus scrofa domesticus (domestic pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 10 | J (J) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A4X1VYD0) Pfam (PF01194) | Sus scrofa domesticus (domestic pig) | |
| 11 | K (K) | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 117 | 13310.3 | 1 | UniProt (F1RKE4) Pfam (PF13656) | Sus scrofa domesticus (domestic pig) | |
| 12 | L (L) | RNA polymerase II, I and III subunit K | polymer | 58 | 7018.2 | 1 | UniProt (A0A4X1TRS6) Pfam (PF03604) | Sus scrofa domesticus (domestic pig) | |
| 13 | M (M) | Transcription elongation factor SPT6 | polymer | 1726 | 199330.7 | 1 | UniProt (Q7KZ85) Pfam (PF14632) Pfam (PF14641) Pfam (PF22706) Pfam (PF14639) Pfam (PF14635) Pfam (PF17674) Pfam (PF00575) Pfam (PF14633) | Homo sapiens (human) | hSPT6,Histone chaperone suppressor of Ty6,Tat-cotransactivator 2 protein,Tat-CT2 protein |
| 14 | N (N) | Non-template DNA | polymer | 63 | 19546.5 | 1 | synthetic construct | ||
| 15 | O (O) | ATP-dependent DNA helicase Q5 | polymer | 991 | 109024.9 | 1 | UniProt (O94762) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) Pfam (PF06959) Pfam (PF08236) | Homo sapiens (human) | DNA 3'-5' helicase RecQ5,DNA helicase,RecQ-like type 5,RecQ5,RecQ protein-like 5 |
| 16 | P (P) | RNA | polymer | 15 | 4854.0 | 1 | synthetic construct | ||
| 17 | Q (Q) | RNA polymerase-associated protein CTR9 homolog | polymer | 1173 | 133715.4 | 1 | UniProt (Q6PD62) Pfam (PF13374) Pfam (PF13181) | Homo sapiens (human) | SH2 domain-binding protein 1 |
| 18 | R (T) | Template DNA | polymer | 48 | 14672.3 | 1 | synthetic construct | ||
| 19 | S (U) | RNA polymerase-associated protein LEO1 | polymer | 666 | 75514.2 | 1 | UniProt (Q8WVC0) Pfam (PF04004) | Homo sapiens (human) | Replicative senescence down-regulated leo1-like protein |
| 20 | T (V) | RNA polymerase II-associated factor 1 homolog | polymer | 531 | 60052.7 | 1 | UniProt (Q8N7H5) Pfam (PF03985) | Homo sapiens (human) | hPAF1,Pancreatic differentiation protein 2 |
| 21 | U (W) | WD repeat-containing protein 61 | polymer | 305 | 33617.5 | 1 | UniProt (Q9GZS3) Pfam (PF00400) | Homo sapiens (human) | Meiotic recombination REC14 protein homolog,SKI8 homolog,Ski8 |
| 22 | V (X) | Parafibromin | polymer | 531 | 60673.5 | 1 | UniProt (Q6P1J9) Pfam (PF16050) Pfam (PF05179) | Homo sapiens (human) | Cell division cycle protein 73 homolog,Hyperparathyroidism 2 protein |
| 23 | W (Y) | Transcription elongation factor SPT4 | polymer | 117 | 13210.2 | 1 | UniProt (P63272) Pfam (PF06093) | Homo sapiens (human) | hSPT4,DRB sensitivity-inducing factor 14 kDa subunit,DSIF p14,DRB sensitivity-inducing factor small subunit,DSIF small subunit |
| 24 | X (Z) | Transcription elongation factor SPT5 | polymer | 1087 | 121145.5 | 1 | UniProt (O00267) Pfam (PF11942) Pfam (PF03439) Pfam (PF00467) | Homo sapiens (human) | hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein |
| 25 | BA, CA, DA, EA, FA... (B, C, I, J, L...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 26 | AA (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 1362741.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 547.6 | |
| All* | Total formula weight | 1363289.4 |
