9HVQ
Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
Functional Information from PROSITE/UniProt
site_id | PS00018 |
Number of Residues | 13 |
Details | EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI |
Chain | Residue | Details |
C | ASP136-ILE148 |
site_id | PS00115 |
Number of Residues | 7 |
Details | RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA |
Chain | Residue | Details |
A | TYR1593-ALA1599 | |
A | TYR1671-SER1677 | |
A | TYR1678-SER1684 | |
A | TYR1685-SER1691 | |
A | TYR1692-SER1698 | |
A | TYR1699-SER1705 | |
A | TYR1706-SER1712 | |
A | TYR1713-SER1719 | |
A | TYR1720-SER1726 | |
A | TYR1727-SER1733 | |
A | TYR1734-SER1740 | |
A | TYR1615-SER1621 | |
A | TYR1741-ASN1747 | |
A | TYR1748-ASN1754 | |
A | TYR1755-SER1761 | |
A | TYR1762-SER1768 | |
A | TYR1769-ASN1775 | |
A | TYR1776-ASN1782 | |
A | TYR1783-SER1789 | |
A | TYR1790-SER1796 | |
A | TYR1797-SER1803 | |
A | TYR1818-SER1824 | |
A | TYR1622-SER1628 | |
A | TYR1825-SER1831 | |
A | TYR1832-LYS1838 | |
A | TYR1839-SER1845 | |
A | TYR1853-LYS1859 | |
A | TYR1860-LYS1866 | |
A | TYR1867-LYS1873 | |
A | TYR1874-THR1880 | |
A | TYR1888-THR1894 | |
A | TYR1902-LYS1908 | |
A | TYR1909-THR1915 | |
A | TYR1629-ASN1635 | |
A | TYR1916-LYS1922 | |
A | TYR1923-THR1929 | |
A | TYR1930-LYS1936 | |
A | TYR1947-THR1953 | |
A | TYR1636-SER1642 | |
A | TYR1643-SER1649 | |
A | TYR1650-SER1656 | |
A | TYR1657-SER1663 | |
A | TYR1664-SER1670 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH |
Chain | Residue | Details |
I | TYR112-HIS118 |
site_id | PS00446 |
Number of Residues | 41 |
Details | RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP |
Chain | Residue | Details |
C | ASN32-PRO72 |
site_id | PS00466 |
Number of Residues | 38 |
Details | ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW |
Chain | Residue | Details |
I | CYS86-TRP123 |
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL |
Chain | Residue | Details |
W | ALA79-LEU93 |
site_id | PS00690 |
Number of Residues | 10 |
Details | DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SyLVVDEAHC |
Chain | Residue | Details |
O | SER152-CYS161 |
site_id | PS01030 |
Number of Residues | 27 |
Details | RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC |
Chain | Residue | Details |
I | PHE16-CYS42 |
site_id | PS01110 |
Number of Residues | 14 |
Details | RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE |
Chain | Residue | Details |
E | HIS142-GLU155 |
site_id | PS01111 |
Number of Residues | 15 |
Details | RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ |
Chain | Residue | Details |
F | THR58-GLN72 |
site_id | PS01112 |
Number of Residues | 10 |
Details | RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG |
Chain | Residue | Details |
J | ILE2-GLY11 |
site_id | PS01154 |
Number of Residues | 32 |
Details | RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP |
Chain | Residue | Details |
K | ILE35-PRO66 |
site_id | PS01166 |
Number of Residues | 13 |
Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT |
Chain | Residue | Details |
B | GLY932-THR944 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI10 |
Number of Residues | 45 |
Details | Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 42 |
Details | Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI15 |
Number of Residues | 106 |
Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI18 |
Number of Residues | 34 |
Details | Repeat: {"description":"TPR 1"} |
Chain | Residue | Details |
site_id | SWS_FT_FI19 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 2"} |
Chain | Residue | Details |
site_id | SWS_FT_FI20 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 3"} |
Chain | Residue | Details |
site_id | SWS_FT_FI21 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 4"} |
Chain | Residue | Details |
site_id | SWS_FT_FI22 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 5"} |
Chain | Residue | Details |
site_id | SWS_FT_FI23 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 6"} |
Chain | Residue | Details |
site_id | SWS_FT_FI24 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 7"} |
Chain | Residue | Details |
site_id | SWS_FT_FI25 |
Number of Residues | 32 |
Details | Repeat: {"description":"TPR 8"} |
Chain | Residue | Details |
site_id | SWS_FT_FI26 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 9"} |
Chain | Residue | Details |
site_id | SWS_FT_FI27 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 10"} |
Chain | Residue | Details |
site_id | SWS_FT_FI28 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 11"} |
Chain | Residue | Details |
site_id | SWS_FT_FI29 |
Number of Residues | 32 |
Details | Repeat: {"description":"TPR 12"} |
Chain | Residue | Details |
site_id | SWS_FT_FI30 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 13"} |
Chain | Residue | Details |
site_id | SWS_FT_FI31 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 14"} |
Chain | Residue | Details |
site_id | SWS_FT_FI32 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 15"} |
Chain | Residue | Details |
site_id | SWS_FT_FI33 |
Number of Residues | 33 |
Details | Repeat: {"description":"TPR 16"} |
Chain | Residue | Details |
site_id | SWS_FT_FI34 |
Number of Residues | 13 |
Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI35 |
Number of Residues | 2 |
Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI36 |
Number of Residues | 43 |
Details | Repeat: {"description":"WD 1"} |
Chain | Residue | Details |
site_id | SWS_FT_FI37 |
Number of Residues | 39 |
Details | Repeat: {"description":"WD 2"} |
Chain | Residue | Details |
site_id | SWS_FT_FI38 |
Number of Residues | 39 |
Details | Repeat: {"description":"WD 3"} |
Chain | Residue | Details |
site_id | SWS_FT_FI39 |
Number of Residues | 41 |
Details | Repeat: {"description":"WD 4"} |
Chain | Residue | Details |
site_id | SWS_FT_FI40 |
Number of Residues | 39 |
Details | Repeat: {"description":"WD 5"} |
Chain | Residue | Details |
site_id | SWS_FT_FI41 |
Number of Residues | 39 |
Details | Repeat: {"description":"WD 6"} |
Chain | Residue | Details |
site_id | SWS_FT_FI42 |
Number of Residues | 33 |
Details | Repeat: {"description":"WD 7"} |
Chain | Residue | Details |
site_id | SWS_FT_FI43 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI44 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI45 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI46 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI47 |
Number of Residues | 31 |
Details | Domain: {"description":"KOW 2"} |
Chain | Residue | Details |
site_id | SWS_FT_FI48 |
Number of Residues | 31 |
Details | Domain: {"description":"KOW 3"} |
Chain | Residue | Details |
site_id | SWS_FT_FI49 |
Number of Residues | 33 |
Details | Domain: {"description":"KOW 4"} |
Chain | Residue | Details |
site_id | SWS_FT_FI50 |
Number of Residues | 33 |
Details | Domain: {"description":"KOW 5"} |
Chain | Residue | Details |
site_id | SWS_FT_FI51 |
Number of Residues | 6 |
Details | Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478862","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI52 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O55201","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |