9HVQ

Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001172	biological_process	RNA-templated transcription
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006366	biological_process	transcription by RNA polymerase II
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0005634	cellular_component	nucleus
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0008270	molecular_function	zinc ion binding
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006366	biological_process	transcription by RNA polymerase II
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0001825	biological_process	blastocyst formation
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0006397	biological_process	mRNA processing
M	0008023	cellular_component	transcription elongation factor complex
M	0008380	biological_process	RNA splicing
M	0031491	molecular_function	nucleosome binding
M	0034728	biological_process	nucleosome organization
M	0042393	molecular_function	histone binding
M	0045191	biological_process	regulation of isotype switching
M	0051028	biological_process	mRNA transport
M	0051147	biological_process	regulation of muscle cell differentiation
M	0140673	biological_process	transcription elongation-coupled chromatin remodeling
O	0000166	molecular_function	nucleotide binding
O	0000278	biological_process	mitotic cell cycle
O	0000724	biological_process	double-strand break repair via homologous recombination
O	0000993	molecular_function	RNA polymerase II complex binding
O	0003677	molecular_function	DNA binding
O	0003678	molecular_function	DNA helicase activity
O	0004386	molecular_function	helicase activity
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005657	cellular_component	replication fork
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006259	biological_process	DNA metabolic process
O	0006260	biological_process	DNA replication
O	0006281	biological_process	DNA repair
O	0006974	biological_process	DNA damage response
O	0009378	molecular_function	four-way junction helicase activity
O	0010605	biological_process	negative regulation of macromolecule metabolic process
O	0016787	molecular_function	hydrolase activity
O	0016853	molecular_function	isomerase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
O	0043138	molecular_function	3'-5' DNA helicase activity
O	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
O	0046872	molecular_function	metal ion binding
O	0051301	biological_process	cell division
O	0051304	biological_process	chromosome separation
O	0071466	biological_process	cellular response to xenobiotic stimulus
O	0072757	biological_process	cellular response to camptothecin
O	0097550	cellular_component	transcription preinitiation complex
O	0140097	molecular_function	catalytic activity, acting on DNA
O	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
O	1990506	biological_process	mitotic DNA-templated DNA replication
O	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000791	cellular_component	euchromatin
Q	0000993	molecular_function	RNA polymerase II complex binding
Q	0001711	biological_process	endodermal cell fate commitment
Q	0001826	biological_process	inner cell mass cell differentiation
Q	0001829	biological_process	trophectodermal cell differentiation
Q	0001832	biological_process	blastocyst growth
Q	0001835	biological_process	blastocyst hatching
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0006325	biological_process	chromatin organization
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
Q	0016055	biological_process	Wnt signaling pathway
Q	0016593	cellular_component	Cdc73/Paf1 complex
Q	0016607	cellular_component	nuclear speck
Q	0019827	biological_process	stem cell population maintenance
Q	0042169	molecular_function	SH2 domain binding
Q	0045638	biological_process	negative regulation of myeloid cell differentiation
Q	0045814	biological_process	negative regulation of gene expression, epigenetic
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0070102	biological_process	interleukin-6-mediated signaling pathway
Q	0071222	biological_process	cellular response to lipopolysaccharide
U	0001650	cellular_component	fibrillar center
U	0001711	biological_process	endodermal cell fate commitment
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005813	cellular_component	centrosome
U	0006368	biological_process	transcription elongation by RNA polymerase II
U	0016055	biological_process	Wnt signaling pathway
U	0016593	cellular_component	Cdc73/Paf1 complex
U	0019827	biological_process	stem cell population maintenance
U	0031124	biological_process	mRNA 3'-end processing
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0045638	biological_process	negative regulation of myeloid cell differentiation
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0000993	molecular_function	RNA polymerase II complex binding
V	0001650	cellular_component	fibrillar center
V	0001711	biological_process	endodermal cell fate commitment
V	0003682	molecular_function	chromatin binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0016020	cellular_component	membrane
V	0016055	biological_process	Wnt signaling pathway
V	0016593	cellular_component	Cdc73/Paf1 complex
V	0019827	biological_process	stem cell population maintenance
V	0031124	biological_process	mRNA 3'-end processing
V	0034504	biological_process	protein localization to nucleus
V	0045638	biological_process	negative regulation of myeloid cell differentiation
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0071222	biological_process	cellular response to lipopolysaccharide
V	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
W	0000791	cellular_component	euchromatin
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0016055	biological_process	Wnt signaling pathway
W	0016593	cellular_component	Cdc73/Paf1 complex
W	0045638	biological_process	negative regulation of myeloid cell differentiation
W	0055087	cellular_component	Ski complex
W	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
W	0072344	biological_process	rescue of stalled ribosome
X	0000122	biological_process	negative regulation of transcription by RNA polymerase II
X	0000781	cellular_component	chromosome, telomeric region
X	0000993	molecular_function	RNA polymerase II complex binding
X	0001558	biological_process	regulation of cell growth
X	0001711	biological_process	endodermal cell fate commitment
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005829	cellular_component	cytosol
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006368	biological_process	transcription elongation by RNA polymerase II
X	0008285	biological_process	negative regulation of cell population proliferation
X	0016055	biological_process	Wnt signaling pathway
X	0016593	cellular_component	Cdc73/Paf1 complex
X	0019827	biological_process	stem cell population maintenance
X	0030177	biological_process	positive regulation of Wnt signaling pathway
X	0031124	biological_process	mRNA 3'-end processing
X	0031442	biological_process	positive regulation of mRNA 3'-end processing
X	0031648	biological_process	protein destabilization
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0043066	biological_process	negative regulation of apoptotic process
X	0045638	biological_process	negative regulation of myeloid cell differentiation
X	0045944	biological_process	positive regulation of transcription by RNA polymerase II
X	0048147	biological_process	negative regulation of fibroblast proliferation
X	0050680	biological_process	negative regulation of epithelial cell proliferation
X	0071222	biological_process	cellular response to lipopolysaccharide
X	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
X	2000134	biological_process	negative regulation of G1/S transition of mitotic cell cycle
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0000993	molecular_function	RNA polymerase II complex binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006368	biological_process	transcription elongation by RNA polymerase II
Y	0008270	molecular_function	zinc ion binding
Y	0032044	cellular_component	DSIF complex
Y	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Y	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Y	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Y	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046872	molecular_function	metal ion binding
Y	0046982	molecular_function	protein heterodimerization activity
Y	0140870	molecular_function	RNA polymerase inhibitor activity
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0003682	molecular_function	chromatin binding
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0016239	biological_process	positive regulation of macroautophagy
Z	0019899	molecular_function	enzyme binding
Z	0032044	cellular_component	DSIF complex
Z	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Z	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0046982	molecular_function	protein heterodimerization activity
Z	0140870	molecular_function	RNA polymerase inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL

Chain	Residue	Details
W	ALA79-LEU93

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SyLVVDEAHC

Chain	Residue	Details
O	SER152-CYS161

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI10
Number of Residues	45
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	106
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	34
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	33
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	33
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	33
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	33
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	32
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	33
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	33
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	33
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	32
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	33
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	33
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	33
Details	Repeat: {"description":"TPR 15"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	33
Details	Repeat: {"description":"TPR 16"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	39
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	33
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	31
Details	Domain: {"description":"KOW 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	31
Details	Domain: {"description":"KOW 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	33
Details	Domain: {"description":"KOW 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	33
Details	Domain: {"description":"KOW 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	6
Details	Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478862","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O55201","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---