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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9HNQ

a5b3 GABAA Receptor bound to GABA and Mb25 in desensitized state in detergent micelles

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)		Green fluorescent protein,Gamma-aminobutyric acid receptor subunit alpha-5polymer67976207.32UniProt (P42212)
UniProt (P31644)		Aequorea victoriaGABA(A) receptor subunit alpha-5,GABAAR subunit alpha-5
2B, C, E
(B, C, E)		Gamma-aminobutyric acid receptor subunit beta-3,Green fluorescent proteinpolymer62371073.43UniProt (P28472)
UniProt (P42212)		Homo sapiens (human)GABA(A) receptor subunit beta-3,GABAAR subunit beta-3
3F
(P)		Mb25polymer54158275.11Escherichia coli
4G
(F)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
5H, I, O
(G, H, N)		beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
6J, N
(I, M)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.02In PDB
GlyTouCan (G09724ZC)
7K
(J)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.01In PDB
8L
(K)		beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.51In PDB
GlyTouCan (G44266EX)
9M
(L)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G35932AR)
10P, S
(B, E)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.12Chemie (ABU)
11Q
(C)		4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACIDnon-polymer238.31Chemie (EPE)
12R
(D)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
Sequence modifications
A, D: -287 - -50 (UniProt: P42212)
PDBExternal DatabaseDetails
Met -315-initiating methionine
Arg -314-expression tag
Lys -313-expression tag
Ser -312-expression tag
Pro -311-expression tag
Gly -310-expression tag
Leu -309-expression tag
Ser -308-expression tag
Asp -307-expression tag
Cys -306-expression tag
Leu -305-expression tag
Trp -304-expression tag
Ala -303-expression tag
Trp -302-expression tag
Ile -301-expression tag
Leu -300-expression tag
Leu -299-expression tag
Leu -298-expression tag
Ser -297-expression tag
Thr -296-expression tag
Leu -295-expression tag
Thr -294-expression tag
Gly -293-expression tag
Arg -292-expression tag
Ser -291-expression tag
Tyr -290-expression tag
Gly -289-expression tag
Gln -288-expression tag
Arg -258Ser 30conflict
Asn -249Tyr 39conflict
Leu -224Phe 64conflict
Thr -223Ser 65conflict
Arg -208Gln 80conflict
Ser -189Phe 99conflict
Thr -183Asn 105conflict
Phe -143Tyr 145conflict
Thr -135Met 153conflict
Ala -125Val 163conflict
Val -117Ile 171conflict
Val -82Ala 206conflict
Ala -49-linker
Ala -48-linker
Asn -47-linker
Ala -46-linker
Leu -45-linker
Ala -44-linker
Ala -43-linker
Trp -42-linker
Ser -41-linker
His -40-linker
Pro -39-linker
Gln -38-linker
Phe -37-linker
Glu -36-linker
Lys -35-linker
Gly -34-linker
Gly -33-linker
Gly -32-linker
Ser -31-linker
Gly -30-linker
Gly -29-linker
Gly -28-linker
Ser -27-linker
Gly -26-linker
Gly -25-linker
Gly -24-linker
Ser -23-linker
Trp -22-linker
Ser -21-linker
His -20-linker
Pro -19-linker
Gln -18-linker
Phe -17-linker
Glu -16-linker
Lys -15-linker
Ser -14-linker
Ser -13-linker
Ser -12-linker
Asn -11-linker
Asn -10-linker
Asn -9-linker
Asn -8-linker
Asn -7-linker
Glu -6-linker
Asn -5-linker
Leu -4-linker
Tyr -3-linker
Phe -2-linker
Gln -1-linker
Ala 0-linker
A, D: 1 - 314 (UniProt: P31644)
A, D: 322 - 363 (UniProt: P31644)
PDBExternal DatabaseDetails
Ser 315-linker
Gln 316-linker
Pro 317-linker
Ala 318-linker
Arg 319-linker
Ala 320-linker
Ala 321-linker
B, C, E: -24 - 307 (UniProt: P28472)
B, C, E: 314 - 552 (UniProt: P42212)
PDBExternal DatabaseDetails
Val 315-insertion
Met 332Leu 18conflict
Arg 339His 25conflict
Arg 344Ser 30conflict
Val 346Glu 32conflict
His 353Tyr 39conflict
Ser 364Thr 50conflict
Leu 378Phe 64conflict
Ser 419Asn 105conflict
Val 438Glu 124conflict
Thr 442Ile 128conflict
Met 459Tyr 145conflict
Val 461Ser 147conflict
Gly 462His 148conflict
Thr 467Met 153conflict
Ala 477Val 163conflict
Glu 480Lys 166conflict
Val 485Ile 171conflict
Gly 489Ser 175conflict
Ser 506Pro 192conflict
Val 517Thr 203conflict
Val 519Ser 205conflict
Lys 520Ala 206conflict
Arg 538Val 224conflict
Pro 545His 231conflict
Gly 553-linker
Arg 554-linker
Ala 555-linker
Ala 556-linker
B, C, E: 557 - 583 (UniProt: P28472)
PDBExternal DatabaseDetails
Ser 308-linker
Gln 309-linker
Pro 310-linker
Gly 311-linker
Arg 312-linker
Ala 313-linker
Ser 584-expression tag
Arg 585-expression tag
Glu 586-expression tag
Asn 587-expression tag
Leu 588-expression tag
Tyr 589-expression tag
Phe 590-expression tag
Gln 591-expression tag
Ala 592-expression tag
His 593-expression tag
His 594-expression tag
His 595-expression tag
His 596-expression tag
His 597-expression tag
His 598-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight423910.0
BranchedNumber of molecules9
Total formula weight6413.9
Non-Polymers*Number of molecules4
Total formula weight665.8
All*Total formula weight430989.6
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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