9HLC

TRPML1 in complex with compound 11

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Mucolipin-1	polymer	628	70518.5	4	UniProt (Q9GZU1) Pfam (PF21381) Pfam (PF08016)	Homo sapiens (human)	ML1,MG-2,Mucolipidin,Transient receptor potential channel mucolipin 1,TRPML1
2	E, F, G, H (E, F, G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	GA, HA, I, J, R... (D, A, B, C)	N-OCTANE	non-polymer		114.2	8	Chemie (OCT) PubChem (356)
4	AA, FA, IA, K, O... (C, D, A, B)	DODECANE	non-polymer		170.3	8	Chemie (D12) PubChem (8182) PubChem (5359624)
5	BA, JA, L, U (C, D, A, B)	(2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate	non-polymer		746.6	4	Chemie (EUJ) PubChem (53394548) PubChem (177449291) PubChem (11657962) PubChem (99647643) PubChem (99647642) PubChem (136212532)
6	CA, DA, M, V (C, D, A, B)	(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol	non-polymer		286.4	4	Chemie (A1IV5) PubChem (16401323) PubChem (1772448) PubChem (13948) PubChem (56775) PubChem (246206) PubChem (16758135) PubChem (25749249) PubChem (1772449) PubChem (1772446) PubChem (928808) PubChem (1241359) PubChem (1551073) PubChem (59912580) PubChem (6546105) PubChem (6710631) PubChem (7002277) PubChem (7002278) PubChem (7060900) PubChem (7067981) PubChem (7067982) PubChem (7091847) PubChem (7091848) PubChem (7091849) PubChem (10884339) PubChem (11862464) PubChem (11875961) PubChem (99722342) PubChem (99722343) PubChem (101235253) PubChem (6976799) PubChem (9903995) PubChem (10979028) PubChem (12598332) PubChem (126736570) PubChem (141793278) PubChem (143489152) PubChem (143505075) PubChem (145606341) PubChem (164003517) PubChem (166652232)
7	EA, N, P, W (D, A, B, C)	Octadecane	non-polymer		254.5	4	Chemie (8K6) PubChem (11635)
8	KA, LA, MA, NA (A, B, C, D)	water	water		18.0	312	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 580 (UniProt: Q9GZU1)

PDB	External Database	Details
Met -47	-	initiating methionine
His -46	-	expression tag
His -45	-	expression tag
His -44	-	expression tag
His -43	-	expression tag
His -42	-	expression tag
His -41	-	expression tag
His -40	-	expression tag
His -39	-	expression tag
Gly -38	-	expression tag
Gly -37	-	expression tag
Ser -36	-	expression tag
Asp -35	-	expression tag
Tyr -34	-	expression tag
Lys -33	-	expression tag
Asp -32	-	expression tag
His -31	-	expression tag
Asp -30	-	expression tag
Gly -29	-	expression tag
Asp -28	-	expression tag
Tyr -27	-	expression tag
Lys -26	-	expression tag
Asp -25	-	expression tag
His -24	-	expression tag
Asp -23	-	expression tag
Ile -22	-	expression tag
Asp -21	-	expression tag
Tyr -20	-	expression tag
Lys -19	-	expression tag
Asp -18	-	expression tag
Asp -17	-	expression tag
Asp -16	-	expression tag
Asp -15	-	expression tag
Lys -14	-	expression tag
Gly -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	282073.9
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	28
	Total formula weight	7426.4
All*	Total formula weight	291197.9

*Water molecules are not included.