Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, AA, BA, FA (p, g, h, o) | Cytoplasmic dynein 1 intermediate chain 2 | polymer | 612 | 68442.1 | 4 | UniProt (Q13409) Pfam (PF11540) Pfam (PF00400) | Homo sapiens (human) | Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2 |
| 2 | B, C (1, 2) | Nuclear mitotic apparatus protein 1,Methylated-DNA--protein-cysteine methyltransferase | polymer | 889 | 99677.2 | 2 | UniProt (Q14980) UniProt (P16455) Pfam (PF21670) Pfam (PF02870) Pfam (PF01035) | Homo sapiens (human) | Nuclear matrix protein-22,NMP-22,Nuclear mitotic apparatus protein,NuMA protein,SP-H antigen,6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase |
| 3 | D, E, F, G, H... (A, B, D, E, F...) | ARP1 actin related protein 1 homolog A | polymer | 376 | 42670.7 | 8 | UniProt (F2Z5G5) Pfam (PF00022) | Sus scrofa (pig) | |
| 4 | J (H) | Actin, cytoplasmic 1 | polymer | 375 | 41782.7 | 1 | UniProt (Q6QAQ1) Pfam (PF00022) | Sus scrofa (pig) | Beta-actin |
| 5 | L (J) | Arp11 | polymer | 417 | 46250.8 | 1 | UniProt (I3LHK5) Pfam (PF00022) | Sus scrofa (pig) | |
| 6 | M (K) | Capping protein (Actin filament) muscle Z-line, alpha 1 | polymer | 286 | 33059.8 | 1 | UniProt (A0PFK5) Pfam (PF01267) | Sus scrofa (pig) | F-actin capping protein alpha 1 subunit,F-actin capping protein subunit alpha 1 |
| 7 | N (L) | F-actin-capping protein subunit beta | polymer | 272 | 30669.8 | 1 | UniProt (A0PFK7) Pfam (PF01115) | Sus scrofa (pig) | CapZ beta |
| 8 | O, P, R, S, V (M, N, P, Q, V) | Dynactin subunit 2 | polymer | 405 | 44704.4 | 5 | UniProt (A0A5G2QD80) Pfam (PF04912) | Sus scrofa (pig) | |
| 9 | Q, T (O, R) | Dynactin subunit 3 | polymer | 186 | 21192.5 | 2 | UniProt (F1SEC0) Pfam (PF07426) | Sus scrofa (pig) | Dynactin subunit 3 isoform 1 |
| 10 | U (U) | Dynactin 6 | polymer | 190 | 20703.9 | 1 | UniProt (D0G6S1) | Sus scrofa (pig) | |
| 11 | W (W) | Dynactin subunit 5 | polymer | 182 | 20150.5 | 1 | UniProt (A0A286ZK88) Pfam (PF21711) | Sus scrofa (pig) | |
| 12 | X (Y) | Dynactin subunit 4 | polymer | 467 | 52920.4 | 1 | UniProt (A0A4X1TB62) Pfam (PF05502) | Sus scrofa (pig) | Dynactin subunit 4 |
| 13 | DA, EA, Y, Z (e, f, m, n) | Cytoplasmic dynein 1 heavy chain 1 | polymer | 4646 | 533055.1 | 4 | UniProt (Q14204) Pfam (PF08385) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) | Homo sapiens (human) | Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic |
| 14 | CA, GA, JA (j, q, u) | Cytoplasmic dynein 1 light intermediate chain 2 | polymer | 492 | 54173.2 | 3 | UniProt (O43237) Pfam (PF05783) | Homo sapiens (human) | Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55 |
| 15 | HA, IA, KA, LA (s, t, w, z) | Dynein light chain roadblock-type 1 | polymer | 96 | 10934.6 | 4 | UniProt (Q9NP97) Pfam (PF03259) | Homo sapiens (human) | Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1 |
| 16 | MA, NA (S, T) | Dynactin subunit 1 | polymer | 1281 | 142015.5 | 2 | UniProt (A0A287B8J2) Pfam (PF01302) Pfam (PF12455) | Sus scrofa (pig) | 150 kDa dynein-associated polypeptide,p150-glued |
| 17 | BB, PA, QA, RA, SA... (C, A, B, D, E...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 8 | Chemie (ADP) | |||
| 18 | VA, XA (H, J) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 19 | AB, YA, ZA (Y) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
p, g, h, o: 1 - 612 (UniProt: Q13409)
1, 2: 1 - 705 (UniProt: Q14980)
1, 2: 708 - 889 (UniProt: P16455)
e, f, m, n: 1 - 4646 (UniProt: Q14204)
| PDB | External Database | Details |
|---|---|---|
| Ser 484 | Thr 484 | conflict |
| Gly 499 | Asp 499 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 706 | - | linker |
| Ser 707 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Arg 737 | Glu 30 | engineered mutation |
| Ile 739 | Lys 32 | engineered mutation |
| Phe 740 | Leu 33 | engineered mutation |
| Ala 769 | Cys 62 | engineered mutation |
| Ser 822 | Gln 115 | engineered mutation |
| His 823 | Gln 116 | engineered mutation |
| Ala 832 | Lys 125 | engineered mutation |
| Thr 834 | Ala 127 | engineered mutation |
| Ala 835 | Arg 128 | engineered mutation |
| Lys 838 | Gly 131 | engineered mutation |
| Thr 839 | Gly 132 | engineered mutation |
| Leu 841 | Met 134 | engineered mutation |
| Ser 842 | Arg 135 | engineered mutation |
| Gln 857 | Cys 150 | engineered mutation |
| Gly 858 | Ser 151 | engineered mutation |
| Asp 859 | Ser 152 | engineered mutation |
| Leu 860 | Gly 153 | engineered mutation |
| Asp 861 | Ala 154 | engineered mutation |
| Gly 864 | Asn 157 | engineered mutation |
| Glu 866 | Ser 159 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 1567 | Arg 1567 | engineered mutation |
| Glu 1610 | Lys 1610 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 41 |
| Total formula weight | 3948442.7 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4628.2 | |
| All* | Total formula weight | 3953070.9 |
