9HHL

Structure of Dynein-Dynactin-NuMA-LIS1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
e	0000166	molecular_function	nucleotide binding
e	0001673	cellular_component	male germ cell nucleus
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005576	cellular_component	extracellular region
e	0005737	cellular_component	cytoplasm
e	0005813	cellular_component	centrosome
e	0005829	cellular_component	cytosol
e	0005856	cellular_component	cytoskeleton
e	0005868	cellular_component	cytoplasmic dynein complex
e	0005874	cellular_component	microtubule
e	0005881	cellular_component	cytoplasmic microtubule
e	0005938	cellular_component	cell cortex
e	0007052	biological_process	mitotic spindle organization
e	0007097	biological_process	nuclear migration
e	0008090	biological_process	retrograde axonal transport
e	0008569	molecular_function	minus-end-directed microtubule motor activity
e	0016020	cellular_component	membrane
e	0030175	cellular_component	filopodium
e	0030286	cellular_component	dynein complex
e	0031122	biological_process	cytoplasmic microtubule organization
e	0032388	biological_process	positive regulation of intracellular transport
e	0033962	biological_process	P-body assembly
e	0034063	biological_process	stress granule assembly
e	0035578	cellular_component	azurophil granule lumen
e	0042802	molecular_function	identical protein binding
e	0045505	molecular_function	dynein intermediate chain binding
e	0051293	biological_process	establishment of spindle localization
e	0051301	biological_process	cell division
e	0051959	molecular_function	dynein light intermediate chain binding
e	0060236	biological_process	regulation of mitotic spindle organization
e	0070062	cellular_component	extracellular exosome
e	0090235	biological_process	regulation of metaphase plate congression
e	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
e	0120162	biological_process	positive regulation of cold-induced thermogenesis
e	1904115	cellular_component	axon cytoplasm
e	1905832	biological_process	positive regulation of spindle assembly
f	0000166	molecular_function	nucleotide binding
f	0001673	cellular_component	male germ cell nucleus
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005576	cellular_component	extracellular region
f	0005737	cellular_component	cytoplasm
f	0005813	cellular_component	centrosome
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005868	cellular_component	cytoplasmic dynein complex
f	0005874	cellular_component	microtubule
f	0005881	cellular_component	cytoplasmic microtubule
f	0005938	cellular_component	cell cortex
f	0007052	biological_process	mitotic spindle organization
f	0007097	biological_process	nuclear migration
f	0008090	biological_process	retrograde axonal transport
f	0008569	molecular_function	minus-end-directed microtubule motor activity
f	0016020	cellular_component	membrane
f	0030175	cellular_component	filopodium
f	0030286	cellular_component	dynein complex
f	0031122	biological_process	cytoplasmic microtubule organization
f	0032388	biological_process	positive regulation of intracellular transport
f	0033962	biological_process	P-body assembly
f	0034063	biological_process	stress granule assembly
f	0035578	cellular_component	azurophil granule lumen
f	0042802	molecular_function	identical protein binding
f	0045505	molecular_function	dynein intermediate chain binding
f	0051293	biological_process	establishment of spindle localization
f	0051301	biological_process	cell division
f	0051959	molecular_function	dynein light intermediate chain binding
f	0060236	biological_process	regulation of mitotic spindle organization
f	0070062	cellular_component	extracellular exosome
f	0090235	biological_process	regulation of metaphase plate congression
f	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
f	0120162	biological_process	positive regulation of cold-induced thermogenesis
f	1904115	cellular_component	axon cytoplasm
f	1905832	biological_process	positive regulation of spindle assembly
g	0001673	cellular_component	male germ cell nucleus
g	0003777	molecular_function	microtubule motor activity
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005813	cellular_component	centrosome
g	0005829	cellular_component	cytosol
g	0005856	cellular_component	cytoskeleton
g	0005868	cellular_component	cytoplasmic dynein complex
g	0005874	cellular_component	microtubule
g	0007018	biological_process	microtubule-based movement
g	0010970	biological_process	transport along microtubule
g	0030286	cellular_component	dynein complex
g	0031982	cellular_component	vesicle
g	0032388	biological_process	positive regulation of intracellular transport
g	0045503	molecular_function	dynein light chain binding
g	0045504	molecular_function	dynein heavy chain binding
g	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
h	0001673	cellular_component	male germ cell nucleus
h	0003777	molecular_function	microtubule motor activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005868	cellular_component	cytoplasmic dynein complex
h	0005874	cellular_component	microtubule
h	0007018	biological_process	microtubule-based movement
h	0010970	biological_process	transport along microtubule
h	0030286	cellular_component	dynein complex
h	0031982	cellular_component	vesicle
h	0032388	biological_process	positive regulation of intracellular transport
h	0045503	molecular_function	dynein light chain binding
h	0045504	molecular_function	dynein heavy chain binding
h	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	0000166	molecular_function	nucleotide binding
H	0001738	biological_process	morphogenesis of a polarized epithelium
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0005886	cellular_component	plasma membrane
H	0005903	cellular_component	brush border
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005925	cellular_component	focal adhesion
H	0007017	biological_process	microtubule-based process
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007409	biological_process	axonogenesis
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019894	molecular_function	kinesin binding
H	0019901	molecular_function	protein kinase binding
H	0030027	cellular_component	lamellipodium
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030424	cellular_component	axon
H	0030863	cellular_component	cortical cytoskeleton
H	0030957	molecular_function	Tat protein binding
H	0032991	cellular_component	protein-containing complex
H	0034333	biological_process	adherens junction assembly
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0043296	cellular_component	apical junction complex
H	0044305	cellular_component	calyx of Held
H	0045176	biological_process	apical protein localization
H	0045202	cellular_component	synapse
H	0048870	biological_process	cell motility
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051726	biological_process	regulation of cell cycle
H	0070160	cellular_component	tight junction
H	0071896	biological_process	protein localization to adherens junction
H	0072749	biological_process	cellular response to cytochalasin B
H	0097433	cellular_component	dense body
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098871	cellular_component	postsynaptic actin cytoskeleton
H	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
H	0098978	cellular_component	glutamatergic synapse
H	0141108	molecular_function	transporter regulator activity
H	0150111	biological_process	regulation of transepithelial transport
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1903076	biological_process	regulation of protein localization to plasma membrane
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990904	cellular_component	ribonucleoprotein complex
j	0000166	molecular_function	nucleotide binding
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000776	cellular_component	kinetochore
j	0001673	cellular_component	male germ cell nucleus
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005770	cellular_component	late endosome
j	0005813	cellular_component	centrosome
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005868	cellular_component	cytoplasmic dynein complex
j	0005874	cellular_component	microtubule
j	0007018	biological_process	microtubule-based movement
j	0016020	cellular_component	membrane
j	0030286	cellular_component	dynein complex
j	0032388	biological_process	positive regulation of intracellular transport
j	0042802	molecular_function	identical protein binding
j	0045504	molecular_function	dynein heavy chain binding
j	1990090	biological_process	cellular response to nerve growth factor stimulus
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005634	cellular_component	nucleus
J	0005856	cellular_component	cytoskeleton
J	0005869	cellular_component	dynactin complex
J	0007010	biological_process	cytoskeleton organization
J	0007017	biological_process	microtubule-based process
J	0098958	biological_process	retrograde axonal transport of mitochondrion
J	1904115	cellular_component	axon cytoplasm
K	0003779	molecular_function	actin binding
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007017	biological_process	microtubule-based process
K	0008290	cellular_component	F-actin capping protein complex
K	0015629	cellular_component	actin cytoskeleton
K	0030036	biological_process	actin cytoskeleton organization
K	0030863	cellular_component	cortical cytoskeleton
K	0051015	molecular_function	actin filament binding
K	0051016	biological_process	barbed-end actin filament capping
K	0051693	biological_process	actin filament capping
L	0003779	molecular_function	actin binding
L	0005856	cellular_component	cytoskeleton
L	0007017	biological_process	microtubule-based process
L	0015629	cellular_component	actin cytoskeleton
L	0030017	cellular_component	sarcomere
L	0051016	biological_process	barbed-end actin filament capping
L	0051693	biological_process	actin filament capping
L	0071203	cellular_component	WASH complex
m	0000166	molecular_function	nucleotide binding
m	0001673	cellular_component	male germ cell nucleus
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005576	cellular_component	extracellular region
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005829	cellular_component	cytosol
m	0005856	cellular_component	cytoskeleton
m	0005868	cellular_component	cytoplasmic dynein complex
m	0005874	cellular_component	microtubule
m	0005881	cellular_component	cytoplasmic microtubule
m	0005938	cellular_component	cell cortex
m	0007052	biological_process	mitotic spindle organization
m	0007097	biological_process	nuclear migration
m	0008090	biological_process	retrograde axonal transport
m	0008569	molecular_function	minus-end-directed microtubule motor activity
m	0016020	cellular_component	membrane
m	0030175	cellular_component	filopodium
m	0030286	cellular_component	dynein complex
m	0031122	biological_process	cytoplasmic microtubule organization
m	0032388	biological_process	positive regulation of intracellular transport
m	0033962	biological_process	P-body assembly
m	0034063	biological_process	stress granule assembly
m	0035578	cellular_component	azurophil granule lumen
m	0042802	molecular_function	identical protein binding
m	0045505	molecular_function	dynein intermediate chain binding
m	0051293	biological_process	establishment of spindle localization
m	0051301	biological_process	cell division
m	0051959	molecular_function	dynein light intermediate chain binding
m	0060236	biological_process	regulation of mitotic spindle organization
m	0070062	cellular_component	extracellular exosome
m	0090235	biological_process	regulation of metaphase plate congression
m	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
m	0120162	biological_process	positive regulation of cold-induced thermogenesis
m	1904115	cellular_component	axon cytoplasm
m	1905832	biological_process	positive regulation of spindle assembly
M	0005737	cellular_component	cytoplasm
M	0005813	cellular_component	centrosome
M	0005856	cellular_component	cytoskeleton
M	0005869	cellular_component	dynactin complex
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0007052	biological_process	mitotic spindle organization
M	0016020	cellular_component	membrane
M	0030286	cellular_component	dynein complex
n	0000166	molecular_function	nucleotide binding
n	0001673	cellular_component	male germ cell nucleus
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005524	molecular_function	ATP binding
n	0005576	cellular_component	extracellular region
n	0005737	cellular_component	cytoplasm
n	0005813	cellular_component	centrosome
n	0005829	cellular_component	cytosol
n	0005856	cellular_component	cytoskeleton
n	0005868	cellular_component	cytoplasmic dynein complex
n	0005874	cellular_component	microtubule
n	0005881	cellular_component	cytoplasmic microtubule
n	0005938	cellular_component	cell cortex
n	0007052	biological_process	mitotic spindle organization
n	0007097	biological_process	nuclear migration
n	0008090	biological_process	retrograde axonal transport
n	0008569	molecular_function	minus-end-directed microtubule motor activity
n	0016020	cellular_component	membrane
n	0030175	cellular_component	filopodium
n	0030286	cellular_component	dynein complex
n	0031122	biological_process	cytoplasmic microtubule organization
n	0032388	biological_process	positive regulation of intracellular transport
n	0033962	biological_process	P-body assembly
n	0034063	biological_process	stress granule assembly
n	0035578	cellular_component	azurophil granule lumen
n	0042802	molecular_function	identical protein binding
n	0045505	molecular_function	dynein intermediate chain binding
n	0051293	biological_process	establishment of spindle localization
n	0051301	biological_process	cell division
n	0051959	molecular_function	dynein light intermediate chain binding
n	0060236	biological_process	regulation of mitotic spindle organization
n	0070062	cellular_component	extracellular exosome
n	0090235	biological_process	regulation of metaphase plate congression
n	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
n	0120162	biological_process	positive regulation of cold-induced thermogenesis
n	1904115	cellular_component	axon cytoplasm
n	1905832	biological_process	positive regulation of spindle assembly
N	0005737	cellular_component	cytoplasm
N	0005813	cellular_component	centrosome
N	0005856	cellular_component	cytoskeleton
N	0005869	cellular_component	dynactin complex
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0007052	biological_process	mitotic spindle organization
N	0016020	cellular_component	membrane
N	0030286	cellular_component	dynein complex
o	0001673	cellular_component	male germ cell nucleus
o	0003777	molecular_function	microtubule motor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005813	cellular_component	centrosome
o	0005829	cellular_component	cytosol
o	0005856	cellular_component	cytoskeleton
o	0005868	cellular_component	cytoplasmic dynein complex
o	0005874	cellular_component	microtubule
o	0007018	biological_process	microtubule-based movement
o	0010970	biological_process	transport along microtubule
o	0030286	cellular_component	dynein complex
o	0031982	cellular_component	vesicle
o	0032388	biological_process	positive regulation of intracellular transport
o	0045503	molecular_function	dynein light chain binding
o	0045504	molecular_function	dynein heavy chain binding
o	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
O	0000776	cellular_component	kinetochore
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005856	cellular_component	cytoskeleton
O	0005869	cellular_component	dynactin complex
O	0007017	biological_process	microtubule-based process
O	0030496	cellular_component	midbody
O	0032154	cellular_component	cleavage furrow
O	0051301	biological_process	cell division
O	0061640	biological_process	cytoskeleton-dependent cytokinesis
p	0001673	cellular_component	male germ cell nucleus
p	0003777	molecular_function	microtubule motor activity
p	0005515	molecular_function	protein binding
p	0005737	cellular_component	cytoplasm
p	0005813	cellular_component	centrosome
p	0005829	cellular_component	cytosol
p	0005856	cellular_component	cytoskeleton
p	0005868	cellular_component	cytoplasmic dynein complex
p	0005874	cellular_component	microtubule
p	0007018	biological_process	microtubule-based movement
p	0010970	biological_process	transport along microtubule
p	0030286	cellular_component	dynein complex
p	0031982	cellular_component	vesicle
p	0032388	biological_process	positive regulation of intracellular transport
p	0045503	molecular_function	dynein light chain binding
p	0045504	molecular_function	dynein heavy chain binding
p	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005856	cellular_component	cytoskeleton
P	0005869	cellular_component	dynactin complex
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0007052	biological_process	mitotic spindle organization
P	0016020	cellular_component	membrane
P	0030286	cellular_component	dynein complex
q	0000166	molecular_function	nucleotide binding
q	0000226	biological_process	microtubule cytoskeleton organization
q	0000776	cellular_component	kinetochore
q	0001673	cellular_component	male germ cell nucleus
q	0005515	molecular_function	protein binding
q	0005524	molecular_function	ATP binding
q	0005770	cellular_component	late endosome
q	0005813	cellular_component	centrosome
q	0005829	cellular_component	cytosol
q	0005856	cellular_component	cytoskeleton
q	0005868	cellular_component	cytoplasmic dynein complex
q	0005874	cellular_component	microtubule
q	0007018	biological_process	microtubule-based movement
q	0016020	cellular_component	membrane
q	0030286	cellular_component	dynein complex
q	0032388	biological_process	positive regulation of intracellular transport
q	0042802	molecular_function	identical protein binding
q	0045504	molecular_function	dynein heavy chain binding
q	1990090	biological_process	cellular response to nerve growth factor stimulus
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005856	cellular_component	cytoskeleton
Q	0005869	cellular_component	dynactin complex
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0007052	biological_process	mitotic spindle organization
Q	0016020	cellular_component	membrane
Q	0030286	cellular_component	dynein complex
R	0000776	cellular_component	kinetochore
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005856	cellular_component	cytoskeleton
R	0005869	cellular_component	dynactin complex
R	0007017	biological_process	microtubule-based process
R	0030496	cellular_component	midbody
R	0032154	cellular_component	cleavage furrow
R	0051301	biological_process	cell division
R	0061640	biological_process	cytoskeleton-dependent cytokinesis
s	0003777	molecular_function	microtubule motor activity
s	0005515	molecular_function	protein binding
s	0005737	cellular_component	cytoplasm
s	0005813	cellular_component	centrosome
s	0005856	cellular_component	cytoskeleton
s	0005868	cellular_component	cytoplasmic dynein complex
s	0005874	cellular_component	microtubule
s	0005929	cellular_component	cilium
s	0007018	biological_process	microtubule-based movement
s	0007632	biological_process	visual behavior
s	0016020	cellular_component	membrane
s	0030286	cellular_component	dynein complex
s	0032388	biological_process	positive regulation of intracellular transport
s	0035721	biological_process	intraciliary retrograde transport
s	0042802	molecular_function	identical protein binding
s	0045505	molecular_function	dynein intermediate chain binding
s	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
s	0097542	cellular_component	ciliary tip
S	0000132	biological_process	establishment of mitotic spindle orientation
S	0000776	cellular_component	kinetochore
S	0000922	cellular_component	spindle pole
S	0005635	cellular_component	nuclear envelope
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005814	cellular_component	centriole
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005874	cellular_component	microtubule
S	0005875	cellular_component	microtubule associated complex
S	0005938	cellular_component	cell cortex
S	0007017	biological_process	microtubule-based process
S	0007077	biological_process	mitotic nuclear membrane disassembly
S	0007097	biological_process	nuclear migration
S	0007528	biological_process	neuromuscular junction development
S	0008017	molecular_function	microtubule binding
S	0010008	cellular_component	endosome membrane
S	0010457	biological_process	centriole-centriole cohesion
S	0015630	cellular_component	microtubule cytoskeleton
S	0015631	molecular_function	tubulin binding
S	0019901	molecular_function	protein kinase binding
S	0021517	biological_process	ventral spinal cord development
S	0030286	cellular_component	dynein complex
S	0030424	cellular_component	axon
S	0030904	cellular_component	retromer complex
S	0031116	biological_process	positive regulation of microtubule polymerization
S	0031252	cellular_component	cell leading edge
S	0032935	molecular_function	sterol sensor activity
S	0032991	cellular_component	protein-containing complex
S	0034454	biological_process	microtubule anchoring at centrosome
S	0035371	cellular_component	microtubule plus-end
S	0036064	cellular_component	ciliary basal body
S	0042147	biological_process	retrograde transport, endosome to Golgi
S	0042632	biological_process	cholesterol homeostasis
S	0043005	cellular_component	neuron projection
S	0043025	cellular_component	neuronal cell body
S	0045171	cellular_component	intercellular bridge
S	0050905	biological_process	neuromuscular process
S	0051301	biological_process	cell division
S	0060236	biological_process	regulation of mitotic spindle organization
S	0061744	biological_process	motor behavior
S	0070050	biological_process	neuron cellular homeostasis
S	0090063	biological_process	positive regulation of microtubule nucleation
S	0090120	biological_process	lysosome to ER cholesterol transport
S	0120103	cellular_component	centriolar subdistal appendage
S	1904398	biological_process	positive regulation of neuromuscular junction development
S	1905515	biological_process	non-motile cilium assembly
S	1990535	biological_process	neuron projection maintenance
t	0003777	molecular_function	microtubule motor activity
t	0005515	molecular_function	protein binding
t	0005737	cellular_component	cytoplasm
t	0005813	cellular_component	centrosome
t	0005856	cellular_component	cytoskeleton
t	0005868	cellular_component	cytoplasmic dynein complex
t	0005874	cellular_component	microtubule
t	0005929	cellular_component	cilium
t	0007018	biological_process	microtubule-based movement
t	0007632	biological_process	visual behavior
t	0016020	cellular_component	membrane
t	0030286	cellular_component	dynein complex
t	0032388	biological_process	positive regulation of intracellular transport
t	0035721	biological_process	intraciliary retrograde transport
t	0042802	molecular_function	identical protein binding
t	0045505	molecular_function	dynein intermediate chain binding
t	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
t	0097542	cellular_component	ciliary tip
T	0000132	biological_process	establishment of mitotic spindle orientation
T	0000776	cellular_component	kinetochore
T	0000922	cellular_component	spindle pole
T	0005635	cellular_component	nuclear envelope
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005814	cellular_component	centriole
T	0005819	cellular_component	spindle
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005874	cellular_component	microtubule
T	0005875	cellular_component	microtubule associated complex
T	0005938	cellular_component	cell cortex
T	0007017	biological_process	microtubule-based process
T	0007077	biological_process	mitotic nuclear membrane disassembly
T	0007097	biological_process	nuclear migration
T	0007528	biological_process	neuromuscular junction development
T	0008017	molecular_function	microtubule binding
T	0010008	cellular_component	endosome membrane
T	0010457	biological_process	centriole-centriole cohesion
T	0015630	cellular_component	microtubule cytoskeleton
T	0015631	molecular_function	tubulin binding
T	0019901	molecular_function	protein kinase binding
T	0021517	biological_process	ventral spinal cord development
T	0030286	cellular_component	dynein complex
T	0030424	cellular_component	axon
T	0030904	cellular_component	retromer complex
T	0031116	biological_process	positive regulation of microtubule polymerization
T	0031252	cellular_component	cell leading edge
T	0032935	molecular_function	sterol sensor activity
T	0032991	cellular_component	protein-containing complex
T	0034454	biological_process	microtubule anchoring at centrosome
T	0035371	cellular_component	microtubule plus-end
T	0036064	cellular_component	ciliary basal body
T	0042147	biological_process	retrograde transport, endosome to Golgi
T	0042632	biological_process	cholesterol homeostasis
T	0043005	cellular_component	neuron projection
T	0043025	cellular_component	neuronal cell body
T	0045171	cellular_component	intercellular bridge
T	0050905	biological_process	neuromuscular process
T	0051301	biological_process	cell division
T	0060236	biological_process	regulation of mitotic spindle organization
T	0061744	biological_process	motor behavior
T	0070050	biological_process	neuron cellular homeostasis
T	0090063	biological_process	positive regulation of microtubule nucleation
T	0090120	biological_process	lysosome to ER cholesterol transport
T	0120103	cellular_component	centriolar subdistal appendage
T	1904398	biological_process	positive regulation of neuromuscular junction development
T	1905515	biological_process	non-motile cilium assembly
T	1990535	biological_process	neuron projection maintenance
u	0000166	molecular_function	nucleotide binding
u	0000226	biological_process	microtubule cytoskeleton organization
u	0000776	cellular_component	kinetochore
u	0001673	cellular_component	male germ cell nucleus
u	0005515	molecular_function	protein binding
u	0005524	molecular_function	ATP binding
u	0005770	cellular_component	late endosome
u	0005813	cellular_component	centrosome
u	0005829	cellular_component	cytosol
u	0005856	cellular_component	cytoskeleton
u	0005868	cellular_component	cytoplasmic dynein complex
u	0005874	cellular_component	microtubule
u	0007018	biological_process	microtubule-based movement
u	0016020	cellular_component	membrane
u	0030286	cellular_component	dynein complex
u	0032388	biological_process	positive regulation of intracellular transport
u	0042802	molecular_function	identical protein binding
u	0045504	molecular_function	dynein heavy chain binding
u	1990090	biological_process	cellular response to nerve growth factor stimulus
U	0000776	cellular_component	kinetochore
U	0005813	cellular_component	centrosome
U	0005856	cellular_component	cytoskeleton
U	0005869	cellular_component	dynactin complex
U	0007017	biological_process	microtubule-based process
U	0007052	biological_process	mitotic spindle organization
U	0015630	cellular_component	microtubule cytoskeleton
U	0070840	molecular_function	dynein complex binding
V	0005737	cellular_component	cytoplasm
V	0005813	cellular_component	centrosome
V	0005856	cellular_component	cytoskeleton
V	0005869	cellular_component	dynactin complex
V	0005874	cellular_component	microtubule
V	0007017	biological_process	microtubule-based process
V	0007052	biological_process	mitotic spindle organization
V	0016020	cellular_component	membrane
V	0030286	cellular_component	dynein complex
w	0003777	molecular_function	microtubule motor activity
w	0005515	molecular_function	protein binding
w	0005737	cellular_component	cytoplasm
w	0005813	cellular_component	centrosome
w	0005856	cellular_component	cytoskeleton
w	0005868	cellular_component	cytoplasmic dynein complex
w	0005874	cellular_component	microtubule
w	0005929	cellular_component	cilium
w	0007018	biological_process	microtubule-based movement
w	0007632	biological_process	visual behavior
w	0016020	cellular_component	membrane
w	0030286	cellular_component	dynein complex
w	0032388	biological_process	positive regulation of intracellular transport
w	0035721	biological_process	intraciliary retrograde transport
w	0042802	molecular_function	identical protein binding
w	0045505	molecular_function	dynein intermediate chain binding
w	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
w	0097542	cellular_component	ciliary tip
W	0000776	cellular_component	kinetochore
W	0005813	cellular_component	centrosome
W	0005856	cellular_component	cytoskeleton
W	0005869	cellular_component	dynactin complex
W	0007017	biological_process	microtubule-based process
Y	0001725	cellular_component	stress fiber
Y	0005813	cellular_component	centrosome
Y	0005856	cellular_component	cytoskeleton
Y	0005869	cellular_component	dynactin complex
Y	0005938	cellular_component	cell cortex
Y	0007017	biological_process	microtubule-based process
Y	0030017	cellular_component	sarcomere
z	0003777	molecular_function	microtubule motor activity
z	0005515	molecular_function	protein binding
z	0005737	cellular_component	cytoplasm
z	0005813	cellular_component	centrosome
z	0005856	cellular_component	cytoskeleton
z	0005868	cellular_component	cytoplasmic dynein complex
z	0005874	cellular_component	microtubule
z	0005929	cellular_component	cilium
z	0007018	biological_process	microtubule-based movement
z	0007632	biological_process	visual behavior
z	0016020	cellular_component	membrane
z	0030286	cellular_component	dynein complex
z	0032388	biological_process	positive regulation of intracellular transport
z	0035721	biological_process	intraciliary retrograde transport
z	0042802	molecular_function	identical protein binding
z	0045505	molecular_function	dynein intermediate chain binding
z	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
z	0097542	cellular_component	ciliary tip

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
L	CYS62-ASP67

---

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
1	ILE850-VAL856

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
H	TRP356-GLU364
A	TRP357-GLU365

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
m	ILE2216-SER2226

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
K	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
K	LYS256-ARG266

---

site_id	PS00845
Number of Residues	32
Details	CAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF

Chain	Residue	Details
S	GLY48-PHE79

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
H	LEU104-ARG116
A	LEU109-ARG121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	164
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	160
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	180
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	160
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	156
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	349
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q99KJ8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	24
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q99KJ8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"O75935","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"Q9BTE1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q9UJW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9QUR2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"Q9UJW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	302
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---