9HB7
Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, B) | Tryptophan 5-hydroxylase 2 | polymer | 372 | 42755.5 | 2 | UniProt (Q8IWU9) Pfam (PF00351) | Homo sapiens (human) | Neuronal tryptophan hydroxylase,Tryptophan 5-monooxygenase 2 |
2 | C, E (A, B) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
3 | D, F (A, B) | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione | non-polymer | 400.4 | 2 | Chemie (JCR) | |||
4 | G, H (A, B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, B: 148 - 490 (UniProt: Q8IWU9)
PDB | External Database | Details |
---|---|---|
Met 119 | - | initiating methionine |
Lys 120 | - | expression tag |
His 121 | - | expression tag |
His 122 | - | expression tag |
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
Gly 128 | - | expression tag |
Ala 129 | - | expression tag |
Ala 130 | - | expression tag |
Gly 131 | - | expression tag |
Thr 132 | - | expression tag |
Ser 133 | - | expression tag |
Leu 134 | - | expression tag |
Tyr 135 | - | expression tag |
Lys 136 | - | expression tag |
Lys 137 | - | expression tag |
Ala 138 | - | expression tag |
Gly 139 | - | expression tag |
Glu 140 | - | expression tag |
Asn 141 | - | expression tag |
Leu 142 | - | expression tag |
Tyr 143 | - | expression tag |
Phe 144 | - | expression tag |
Gln 145 | - | expression tag |
Gly 146 | - | expression tag |
Ser 147 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85510.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 912.6 | |
All* | Total formula weight | 86423.5 |