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9HB7

Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Tryptophan 5-hydroxylase 2polymer37242755.52UniProt (Q8IWU9)
Pfam (PF00351)
Homo sapiens (human)Neuronal tryptophan hydroxylase,Tryptophan 5-monooxygenase 2
2C, E
(A, B)
FE (III) IONnon-polymer55.82Chemie (FE)
3D, F
(A, B)
8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dionenon-polymer400.42Chemie (JCR)
4G, H
(A, B)
waterwater18.02Chemie (HOH)
Sequence modifications
A, B: 148 - 490 (UniProt: Q8IWU9)
PDBExternal DatabaseDetails
Met 119-initiating methionine
Lys 120-expression tag
His 121-expression tag
His 122-expression tag
His 123-expression tag
His 124-expression tag
His 125-expression tag
His 126-expression tag
His 127-expression tag
Gly 128-expression tag
Ala 129-expression tag
Ala 130-expression tag
Gly 131-expression tag
Thr 132-expression tag
Ser 133-expression tag
Leu 134-expression tag
Tyr 135-expression tag
Lys 136-expression tag
Lys 137-expression tag
Ala 138-expression tag
Gly 139-expression tag
Glu 140-expression tag
Asn 141-expression tag
Leu 142-expression tag
Tyr 143-expression tag
Phe 144-expression tag
Gln 145-expression tag
Gly 146-expression tag
Ser 147-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight85510.9
Non-Polymers*Number of molecules4
Total formula weight912.6
All*Total formula weight86423.5
*Water molecules are not included.

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PDB entries from 2025-07-23

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