9HB7
Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
Functional Information from PROSITE/UniProt
| site_id | PS00367 |
| Number of Residues | 12 |
| Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP |
| Chain | Residue | Details |
| A | PRO314-PRO325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36046836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40534674","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2014","submissionDatabase":"PDB data bank","title":"Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain.","authors":["Kopec J.","Oberholzer A.","Fitzpatrick F.","Newman J.","Tallant C.","Shrestha L.","Burgess-Brown N.","von Delft F.","Arrowsmith C.","Edwards A.","Bountra C.","Yue W.W."]}},{"source":"PDB","id":"4V06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HB8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
