9HB3

cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mambaquaretin-1	polymer	57	6329.2	1	UniProt (A0A1Z0YU59) Pfam (PF00014)	Dendroaspis angusticeps	MQ-1,MQ1,Upsilon-Da2a
2	B (H)	Synthetic antibody, anti-BRIL Fab fragment, Heavy chain	polymer	231	24539.3	1		Homo sapiens
3	C (K)	anti-BRIL Fab Nanobody	polymer	141	15654.1	1		Homo sapiens
4	D (L)	Synthetic antibody, anti-BRIL Fab fragment, Light chain	polymer	215	23541.2	1		Homo sapiens
5	E (R)	arginine-vasopressin (AVP) V2 receptor (V2R)-BRIL,Vasopressin V2 receptor,Vasopressin V2 receptor	polymer	552	60330.1	1	UniProt (P30518) Pfam (PF00001)	Homo sapiens	V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor

Sequence modifications

A: 1 - 57 (UniProt: A0A1Z0YU59)

PDB	External Database	Details
Ala 39	Lys 39	variant

R: -63 - 3 (PDB: 9HB3)
R: 4 - 470 (UniProt: P30518)

PDB	External Database	Details
Gln 22	Asn 22	conflict

R: 471 - 616 (PDB: 9HB3)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	130393.9
All*	Total formula weight	130393.9

*Water molecules are not included.