9HB3
cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| R | 0001992 | biological_process | regulation of systemic arterial blood pressure by vasopressin |
| R | 0003084 | biological_process | positive regulation of systemic arterial blood pressure |
| R | 0003092 | biological_process | renal water retention |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005000 | molecular_function | vasopressin receptor activity |
| R | 0005506 | molecular_function | iron ion binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005768 | cellular_component | endosome |
| R | 0005783 | cellular_component | endoplasmic reticulum |
| R | 0005794 | cellular_component | Golgi apparatus |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0007190 | biological_process | activation of adenylate cyclase activity |
| R | 0007599 | biological_process | hemostasis |
| R | 0008284 | biological_process | positive regulation of cell population proliferation |
| R | 0008285 | biological_process | negative regulation of cell population proliferation |
| R | 0009055 | molecular_function | electron transfer activity |
| R | 0010628 | biological_process | positive regulation of gene expression |
| R | 0016020 | cellular_component | membrane |
| R | 0020037 | molecular_function | heme binding |
| R | 0021537 | biological_process | telencephalon development |
| R | 0022900 | biological_process | electron transport chain |
| R | 0030139 | cellular_component | endocytic vesicle |
| R | 0030669 | cellular_component | clathrin-coated endocytic vesicle membrane |
| R | 0032870 | biological_process | cellular response to hormone stimulus |
| R | 0035811 | biological_process | negative regulation of urine volume |
| R | 0038023 | molecular_function | signaling receptor activity |
| R | 0042597 | cellular_component | periplasmic space |
| R | 0045777 | biological_process | positive regulation of blood pressure |
| R | 0045907 | biological_process | positive regulation of vasoconstriction |
| R | 0048471 | cellular_component | perinuclear region of cytoplasm |
| R | 0070295 | biological_process | renal water absorption |
| R | 1902533 | biological_process | positive regulation of intracellular signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASSyMILAMTLDRHRaI |
| Chain | Residue | Details |
| R | ALA125-ILE141 |
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FtyGGCagnanrFstiekC |
| Chain | Residue | Details |
| A | PHE33-CYS51 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR194-HIS200 | |
| H | TYR208-HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Region: {"description":"Important for binding V2R","evidences":[{"source":"PubMed","id":"28630289","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
