9H9P

Spokes 12 and 13 of the human gamma-tubulin ring complex in complex with CDK5RAP2 and docked MZT2/GCP2-NHD module

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, G)	CDK5 regulatory subunit-associated protein 2	polymer	1893	215417.4	2	UniProt (Q96SN8) Pfam (PF07989)	Homo sapiens (human)	CDK5 activator-binding protein C48,Centrosome-associated protein 215
2	C (L)	Gamma-tubulin complex component 6	polymer	1819	200733.6	1	UniProt (Q96RT7) Pfam (PF19340) Pfam (PF17681) Pfam (PF04130)	Homo sapiens (human)	GCP-6
3	D (M)	Isoform 3 of Gamma-tubulin complex component 2	polymer	930	105765.7	1	UniProt (Q9BSJ2) Pfam (PF17681) Pfam (PF04130)	Homo sapiens (human)	GCP-2,hGCP2,Gamma-ring complex protein 103 kDa,h103p,hGrip103,Spindle pole body protein Spc97 homolog,hSpc97
4	E, F (l, m)	Tubulin gamma-1 chain	polymer	451	51255.8	2	UniProt (P23258) Pfam (PF00091) Pfam (PF03953)	Homo sapiens (human)	Gamma-1-tubulin,Gamma-tubulin complex component 1,GCP-1
5	G (C)	Mitotic-spindle organizing protein 2A	polymer	158	16240.6	1	UniProt (Q6P582) Pfam (PF12926)	Homo sapiens (human)	Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A
6	H, I (l, m)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)

Sequence modifications

A, G: 1 - 1893 (UniProt: Q96SN8)

PDB	External Database	Details
Gln 289	Glu 289	variant
Phe 631	Ser 631	conflict
Leu 1540	Val 1540	variant

l, m: 1 - 451 (UniProt: P23258)

PDB	External Database	Details
Ala 35	Gly 35	conflict
Leu 202	Val 202	conflict

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	856086.3
Non-Polymers*	Number of molecules	2
	Total formula weight	886.4
All*	Total formula weight	856972.7

*Water molecules are not included.