9H9P

Spokes 12 and 13 of the human gamma-tubulin ring complex in complex with CDK5RAP2 and docked MZT2/GCP2-NHD module

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000242	cellular_component	pericentriolar material
A	0000922	cellular_component	spindle pole
A	0000931	cellular_component	gamma-tubulin ring complex
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001578	biological_process	microtubule bundle formation
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007059	biological_process	chromosome segregation
A	0007098	biological_process	centrosome cycle
A	0007099	biological_process	centriole replication
A	0007420	biological_process	brain development
A	0008017	molecular_function	microtubule binding
A	0015631	molecular_function	tubulin binding
A	0019901	molecular_function	protein kinase binding
A	0022008	biological_process	neurogenesis
A	0030054	cellular_component	cell junction
A	0031023	biological_process	microtubule organizing center organization
A	0031116	biological_process	positive regulation of microtubule polymerization
A	0035371	cellular_component	microtubule plus-end
A	0036064	cellular_component	ciliary basal body
A	0043015	molecular_function	gamma-tubulin binding
A	0044877	molecular_function	protein-containing complex binding
A	0045664	biological_process	regulation of neuron differentiation
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046600	biological_process	negative regulation of centriole replication
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070062	cellular_component	extracellular exosome
A	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
A	0097431	cellular_component	mitotic spindle pole
C	0000931	cellular_component	gamma-tubulin ring complex
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
G	0000132	biological_process	establishment of mitotic spindle orientation
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000242	cellular_component	pericentriolar material
G	0000922	cellular_component	spindle pole
G	0000931	cellular_component	gamma-tubulin ring complex
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001578	biological_process	microtubule bundle formation
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005813	cellular_component	centrosome
G	0005815	cellular_component	microtubule organizing center
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007059	biological_process	chromosome segregation
G	0007098	biological_process	centrosome cycle
G	0007099	biological_process	centriole replication
G	0007420	biological_process	brain development
G	0008017	molecular_function	microtubule binding
G	0015631	molecular_function	tubulin binding
G	0019901	molecular_function	protein kinase binding
G	0022008	biological_process	neurogenesis
G	0030054	cellular_component	cell junction
G	0031023	biological_process	microtubule organizing center organization
G	0031116	biological_process	positive regulation of microtubule polymerization
G	0035371	cellular_component	microtubule plus-end
G	0036064	cellular_component	ciliary basal body
G	0043015	molecular_function	gamma-tubulin binding
G	0044877	molecular_function	protein-containing complex binding
G	0045664	biological_process	regulation of neuron differentiation
G	0045665	biological_process	negative regulation of neuron differentiation
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0046600	biological_process	negative regulation of centriole replication
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0070062	cellular_component	extracellular exosome
G	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
G	0097431	cellular_component	mitotic spindle pole
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0000930	cellular_component	gamma-tubulin complex
L	0000931	cellular_component	gamma-tubulin ring complex
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005815	cellular_component	microtubule organizing center
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007020	biological_process	microtubule nucleation
L	0008017	molecular_function	microtubule binding
L	0016020	cellular_component	membrane
L	0031122	biological_process	cytoplasmic microtubule organization
L	0043015	molecular_function	gamma-tubulin binding
L	0051011	molecular_function	microtubule minus-end binding
L	0051225	biological_process	spindle assembly
L	0051321	biological_process	meiotic cell cycle
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000922	cellular_component	spindle pole
M	0005815	cellular_component	microtubule organizing center
M	0007020	biological_process	microtubule nucleation
M	0043015	molecular_function	gamma-tubulin binding
l	0000070	biological_process	mitotic sister chromatid segregation
l	0000166	molecular_function	nucleotide binding
l	0000212	biological_process	meiotic spindle organization
l	0000226	biological_process	microtubule cytoskeleton organization
l	0000242	cellular_component	pericentriolar material
l	0000278	biological_process	mitotic cell cycle
l	0000794	cellular_component	condensed nuclear chromosome
l	0000930	cellular_component	gamma-tubulin complex
l	0000931	cellular_component	gamma-tubulin ring complex
l	0005200	molecular_function	structural constituent of cytoskeleton
l	0005515	molecular_function	protein binding
l	0005525	molecular_function	GTP binding
l	0005634	cellular_component	nucleus
l	0005737	cellular_component	cytoplasm
l	0005813	cellular_component	centrosome
l	0005814	cellular_component	centriole
l	0005819	cellular_component	spindle
l	0005827	cellular_component	polar microtubule
l	0005829	cellular_component	cytosol
l	0005856	cellular_component	cytoskeleton
l	0005874	cellular_component	microtubule
l	0005876	cellular_component	spindle microtubule
l	0005881	cellular_component	cytoplasmic microtubule
l	0005929	cellular_component	cilium
l	0007017	biological_process	microtubule-based process
l	0007020	biological_process	microtubule nucleation
l	0007052	biological_process	mitotic spindle organization
l	0015630	cellular_component	microtubule cytoskeleton
l	0031122	biological_process	cytoplasmic microtubule organization
l	0031252	cellular_component	cell leading edge
l	0036064	cellular_component	ciliary basal body
l	0042802	molecular_function	identical protein binding
l	0043005	cellular_component	neuron projection
l	0045177	cellular_component	apical part of cell
l	0055037	cellular_component	recycling endosome
l	0097730	cellular_component	non-motile cilium
l	0140490	molecular_function	microtubule nucleator activity
l	1990498	cellular_component	mitotic spindle microtubule
m	0000070	biological_process	mitotic sister chromatid segregation
m	0000166	molecular_function	nucleotide binding
m	0000212	biological_process	meiotic spindle organization
m	0000226	biological_process	microtubule cytoskeleton organization
m	0000242	cellular_component	pericentriolar material
m	0000278	biological_process	mitotic cell cycle
m	0000794	cellular_component	condensed nuclear chromosome
m	0000930	cellular_component	gamma-tubulin complex
m	0000931	cellular_component	gamma-tubulin ring complex
m	0005200	molecular_function	structural constituent of cytoskeleton
m	0005515	molecular_function	protein binding
m	0005525	molecular_function	GTP binding
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005814	cellular_component	centriole
m	0005819	cellular_component	spindle
m	0005827	cellular_component	polar microtubule
m	0005829	cellular_component	cytosol
m	0005856	cellular_component	cytoskeleton
m	0005874	cellular_component	microtubule
m	0005876	cellular_component	spindle microtubule
m	0005881	cellular_component	cytoplasmic microtubule
m	0005929	cellular_component	cilium
m	0007017	biological_process	microtubule-based process
m	0007020	biological_process	microtubule nucleation
m	0007052	biological_process	mitotic spindle organization
m	0015630	cellular_component	microtubule cytoskeleton
m	0031122	biological_process	cytoplasmic microtubule organization
m	0031252	cellular_component	cell leading edge
m	0036064	cellular_component	ciliary basal body
m	0042802	molecular_function	identical protein binding
m	0043005	cellular_component	neuron projection
m	0045177	cellular_component	apical part of cell
m	0055037	cellular_component	recycling endosome
m	0097730	cellular_component	non-motile cilium
m	0140490	molecular_function	microtubule nucleator activity
m	1990498	cellular_component	mitotic spindle microtubule

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. AGGTGSG

Chain	Residue	Details
l	ALA142-GLY148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
M	TYR83
G	SER547

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR1001
G	THR1001

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1238
G	SER1238

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1490
G	SER1490

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JLH5

Chain	Residue	Details
A	SER1663
A	SER1666
G	SER1663
G	SER1666

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER1893
G	SER1893

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