9H8T
Cryo-EM structure of the atovaquone-inhibited Complex III from the Chlorocebus sabaeus respirasome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, L (D, d) | Cytochrome c1 | polymer | 325 | 35268.7 | 2 | UniProt (A0A0D9R8S7) Pfam (PF02167) | Chlorocebus sabaeus (green monkey) | |
| 2 | B, K, M (A, T, a) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 274 | 29817.2 | 3 | UniProt (A0A0D9QXW2) Pfam (PF09165) Pfam (PF02921) Pfam (PF00355) | Chlorocebus sabaeus (green monkey) | |
| 3 | C, N (G, g) | Cytochrome b-c1 complex subunit 7 | polymer | 111 | 13540.5 | 2 | UniProt (A0A0D9RJ49) Pfam (PF02271) | Chlorocebus sabaeus (green monkey) | |
| 4 | D, O (C, c) | Cytochrome b-c1 complex subunit 8 | polymer | 82 | 9748.3 | 2 | UniProt (A0A0D9RML3) Pfam (PF02939) | Chlorocebus sabaeus (green monkey) | Complex III subunit 8 |
| 5 | E, P (E, e) | Complex III subunit 9 | polymer | 63 | 7320.5 | 2 | UniProt (A0A0D9RB67) Pfam (PF05365) | Chlorocebus sabaeus (green monkey) | |
| 6 | F, Q (F, f) | Cytochrome b-c1 complex subunit 6 | polymer | 91 | 10804.0 | 2 | UniProt (A0A0D9S9I7) Pfam (PF02320) | Chlorocebus sabaeus (green monkey) | |
| 7 | G, R (K, k) | Ubiquinol-cytochrome c reductase core protein 2 | polymer | 453 | 48593.0 | 2 | UniProt (A0A0D9R493) Pfam (PF00675) Pfam (PF05193) | Chlorocebus sabaeus (green monkey) | |
| 8 | H, S (J, j) | Cytochrome b | polymer | 380 | 43070.8 | 2 | UniProt (Q1AL63) Pfam (PF00033) Pfam (PF00032) | Chlorocebus sabaeus (green monkey) | |
| 9 | I, T (L, l) | Ubiquinol-cytochrome c reductase core protein 1 | polymer | 480 | 52885.8 | 2 | Pfam (PF00675) Pfam (PF05193) UniProt (by SIFTS) (A0A0D9RSN1) | Chlorocebus sabaeus (green monkey) | |
| 10 | J, U (H, h) | UQCRB | polymer | 56 | 6623.7 | 2 | Pfam (PF08997) UniProt (by SIFTS) (A0A2K5HV75) | Chlorocebus sabaeus | |
| 11 | IA, V (d, D) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 12 | JA, W (d, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 13 | KA, X (a, A) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 14 | GA, LA, TA, Y (L, c, l, C) | CARDIOLIPIN | non-polymer | 1464.0 | 4 | Chemie (CDL) | |||
| 15 | MA, Z (e, E) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 16 | AA, NA (J, j) | 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione | non-polymer | 366.8 | 2 | Chemie (AOQ) | |||
| 17 | BA, CA, HA, OA, PA... (J, L, j, l) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 6 | Chemie (PEE) | |||
| 18 | DA, QA (J, j) | 2-[4-(4-CHLOROPHENYL)CYCLOHEXYLIDENE]-3,4-DIHYDROXY-1(2H)-NAPHTHALENONE | non-polymer | 366.8 | 2 | Chemie (AFI) | |||
| 19 | EA, FA, RA, SA (J, j) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 20 | VA, WA (J, j) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
G, g: 1 - 111 (UniProt: A0A0D9RJ49)
K, k: 1 - 453 (UniProt: A0A0D9R493)
| PDB | External Database | Details |
|---|---|---|
| Asp 43 | Glu 43 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 100 | Ile 100 | conflict |
| Val 439 | Ala 439 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 545161.7 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 17553.4 | |
| All* | Total formula weight | 562715.2 |
