9H74
Late-stage 48S Initiation Complex with eIF3 (LS48S-eIF3 IC) guided by the trans-RNA
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Initiator methionylated tRNA | polymer | 76 | 24721.8 | 1 | Oryctolagus cuniculus | ||
| 2 | B (2) | 18S ribosomal RNA | polymer | 1863 | 601015.7 | 1 | Oryctolagus cuniculus | ||
| 3 | C (3) | Linear mRNA | polymer | 160 | 51665.8 | 1 | Oryctolagus cuniculus | ||
| 4 | D (A) | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 390 | 44692.5 | 1 | UniProt (G1T2G4) Pfam (PF00575) Pfam (PF07541) | Oryctolagus cuniculus (rabbit) | Eukaryotic translation initiation factor 2 subunit alpha |
| 5 | E (B) | protein-synthesizing GTPase | polymer | 485 | 52500.0 | 1 | UniProt (A0A5F9C3W2) Pfam (PF00009) Pfam (PF03144) Pfam (PF09173) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (C) | 40S ribosomal protein SA | polymer | 295 | 32928.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) | Oryctolagus cuniculus (rabbit) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 7 | G (D) | 40S ribosomal protein S3a | polymer | 264 | 29929.0 | 1 | UniProt (G1TN72) Pfam (PF01015) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (E) | Small ribosomal subunit protein uS5 | polymer | 270 | 29100.0 | 1 | UniProt (A0AAA9WW19) Pfam (PF00333) Pfam (PF03719) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S2 |
| 9 | I (F) | Ribosomal protein S3 | polymer | 243 | 26715.3 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (rabbit) | |
| 10 | J (G) | 40S ribosomal protein S4 | polymer | 263 | 29658.9 | 1 | UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (H) | Ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (rabbit) | |
| 12 | L (I) | Small ribosomal subunit protein eS6 | polymer | 249 | 28755.9 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S6 |
| 13 | M (J) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (G1SVB0) Pfam (PF01251) | Oryctolagus cuniculus (rabbit) | |
| 14 | N (K) | Small ribosomal subunit protein eS8 | polymer | 208 | 24163.2 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S8 |
| 15 | O (L) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (rabbit) | |
| 16 | P (M) | Small ribosomal subunit protein eS10 | polymer | 149 | 17156.9 | 1 | UniProt (G1U0Y5) Pfam (PF03501) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S10 |
| 17 | Q (N) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (O) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (P) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (rabbit) | uS15 |
| 20 | T (Q) | 40S ribosomal protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (G1T1F0) Pfam (PF00411) | Oryctolagus cuniculus (rabbit) | |
| 21 | U (R) | 40S ribosomal protein uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (rabbit) | |
| 22 | V (S) | Ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (T) | 40S ribosomal protein eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (rabbit) | |
| 24 | X (U) | 40S ribosomal protein uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (rabbit) | |
| 25 | Y (V) | 40S ribosomal protein eS19 | polymer | 145 | 16235.8 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (rabbit) | |
| 26 | Z (W) | 40S ribosomal protein uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (X) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 1 | UniProt (Q32PB8) Pfam (PF01249) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (Y) | Ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (Z) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (rabbit) | RPS23 |
| 30 | DA (a) | 40S ribosomal protein S24 | polymer | 133 | 15434.3 | 1 | UniProt (G1TS40) Pfam (PF01282) | Oryctolagus cuniculus (rabbit) | |
| 31 | EA (b) | 40S ribosomal protein S26 | polymer | 115 | 12961.5 | 1 | UniProt (G1TFE8) Pfam (PF01283) | Oryctolagus cuniculus (rabbit) | |
| 32 | FA (c) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (d) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (rabbit) | |
| 34 | HA (e) | 40S ribosomal protein S29 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (rabbit) | uS14 |
| 35 | IA (f) | Ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (g) | Small ribosomal subunit protein RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (rabbit) | RACK1 |
| 37 | KA (i) | 40S ribosomal protein S30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (j) | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16476.4 | 1 | UniProt (P47813) Pfam (PF01176) | Oryctolagus cuniculus (rabbit) | eIF-1A X isoform,eIF1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
| 39 | MA (k) | ATP binding cassette subfamily E member 1 | polymer | 599 | 67419.3 | 1 | UniProt (A0A5K1V8K4) Pfam (PF04068) Pfam (PF00037) Pfam (PF00005) | Oryctolagus cuniculus (rabbit) | ATP-binding cassette sub-family E member 1,ATP-binding cassette,sub-family E (OABP),member 1 |
| 40 | NA (l) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | |
| 41 | OA (m) | Eukaryotic translation initiation factor 3 subunit D | polymer | 557 | 64959.7 | 1 | UniProt (G1SQV5) Pfam (PF05091) | Oryctolagus cuniculus (rabbit) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta |
| 42 | PA (n) | 40S ribosomal protein S25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (rabbit) | |
| 43 | QA (o) | Eukaryotic translation initiation factor 5 | polymer | 430 | 49131.5 | 1 | UniProt (G1TGW1) Pfam (PF01873) Pfam (PF02020) | Oryctolagus cuniculus (rabbit) | |
| 44 | RA (q) | Eukaryotic translation initiation factor 3 subunit F | polymer | 364 | 37846.7 | 1 | UniProt (G1SLC2) Pfam (PF01398) Pfam (PF13012) | Oryctolagus cuniculus (rabbit) | eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 45 | SA (r) | Eukaryotic translation initiation factor 3 subunit H | polymer | 352 | 39955.3 | 1 | UniProt (A0A1U7U441) Pfam (PF01398) Pfam (PF19445) | Oryctolagus cuniculus (rabbit) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3 gamma,eIF3 p40 subunit |
| 46 | TA (s) | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25129.7 | 1 | UniProt (G1T3L2) Pfam (PF10075) | Oryctolagus cuniculus (rabbit) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,eIF-3 p25 |
| 47 | UA (t) | Eukaryotic translation initiation factor 3 subunit L | polymer | 607 | 71001.5 | 1 | UniProt (G1SED9) Pfam (PF10255) | Oryctolagus cuniculus (rabbit) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 48 | VA (u) | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (G1SLW8) Pfam (PF01399) Pfam (PF18005) | Oryctolagus cuniculus (rabbit) | eIF3m |
| 49 | WA (v) | Eukaryotic translation initiation factor 3 subunit C | polymer | 913 | 105676.2 | 1 | UniProt (G1U971) Pfam (PF05470) Pfam (PF01399) Pfam (PF26569) | Oryctolagus cuniculus (rabbit) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 50 | XA (w) | Eukaryotic translation initiation factor 3 subunit E | polymer | 462 | 54199.9 | 1 | UniProt (G1SUC8) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | Oryctolagus cuniculus (rabbit) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,eIF-3 p48 |
| 51 | YA (y) | Eukaryotic translation initiation factor 3 subunit A | polymer | 1362 | 164902.7 | 1 | UniProt (G1SMZ5) Pfam (PF22591) Pfam (PF01399) | Oryctolagus cuniculus (rabbit) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta |
| 52 | AB, ZA (k) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) |
Sequence modifications
A: 1 - 284 (UniProt: G1T2G4)
A: 285 - 390 (UniProt: G1T2G4)
B: 1 - 485 (UniProt: A0A5F9C3W2)
I: 1 - 249 (UniProt: G1TM55)
j: 1 - 144 (UniProt: P47813)
A: 285 - 390 (UniProt: G1T2G4)
B: 1 - 485 (UniProt: A0A5F9C3W2)
| PDB | External Database | Details |
|---|---|---|
| - | Unk 367 | deletion |
| - | Unk 368 | deletion |
| - | Unk 369 | deletion |
| - | Unk 370 | deletion |
| - | Unk 371 | deletion |
| - | Unk 372 | deletion |
| - | Unk 373 | deletion |
| - | Unk 374 | deletion |
| - | Unk 375 | deletion |
| - | Unk 376 | deletion |
| - | Unk 377 | deletion |
| - | Unk 378 | deletion |
| - | Unk 379 | deletion |
| - | Unk 380 | deletion |
| - | Unk 381 | deletion |
| Val 367 | Unk 382 | conflict |
| Gly 368 | Unk 383 | conflict |
| Gln 369 | Unk 384 | conflict |
| Val 370 | Unk 385 | conflict |
| Leu 371 | Unk 386 | conflict |
| Gly 372 | Unk 387 | conflict |
| Ala 373 | Unk 388 | conflict |
| Val 374 | Unk 389 | conflict |
| Gly 375 | Unk 390 | conflict |
| Ala 376 | Unk 391 | conflict |
| Leu 377 | Unk 392 | conflict |
| Pro 378 | Unk 393 | conflict |
| Glu 379 | Unk 394 | conflict |
| Ile 380 | Unk 395 | conflict |
| Phe 381 | Unk 396 | conflict |
| Thr 382 | Unk 397 | conflict |
| Glu 383 | Unk 398 | conflict |
| Leu 384 | Unk 399 | conflict |
| Glu 385 | Unk 400 | conflict |
| Ile 386 | Unk 401 | conflict |
| Ser 387 | Unk 402 | conflict |
| Tyr 388 | Unk 403 | conflict |
| Phe 389 | Unk 404 | conflict |
| Leu 390 | Unk 405 | conflict |
| Leu 391 | Unk 406 | conflict |
| Arg 392 | Unk 407 | conflict |
| Arg 393 | Unk 408 | conflict |
| Leu 394 | Unk 409 | conflict |
| Leu 395 | Unk 410 | conflict |
| Gly 396 | Unk 411 | conflict |
| Val 397 | Unk 412 | conflict |
| Arg 398 | Unk 413 | conflict |
| Thr 399 | Unk 414 | conflict |
| Glu 400 | Unk 415 | conflict |
| Gly 401 | Unk 416 | conflict |
| Asp 402 | Unk 417 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 130 | Pro 130 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 141 | Ile 141 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 51 |
| Total formula weight | 2140018.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 703.3 | |
| All* | Total formula weight | 2140721.3 |
