9H1Z

Cryo-EM Structure of human OAS2 Dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	2'-5'-oligoadenylate synthase 2	polymer	739	84750.9	2	UniProt (P29728) Pfam (PF10421) Pfam (PF01909)	Homo sapiens (human)	(2-5')oligo(A) synthase 2,2-5A synthase 2,p69 OAS / p71 OAS,p69OAS / p71OAS
2	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A, B: 1 - 719 (UniProt: P29728)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ala -9	-	expression tag
Ala -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	169501.9
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	169567.3

*Water molecules are not included.