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9H1Z

Cryo-EM Structure of human OAS2 Dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001730molecular_function2'-5'-oligoadenylate synthetase activity
A0002376biological_processimmune system process
A0003723molecular_functionRNA binding
A0003725molecular_functiondouble-stranded RNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006139biological_processnucleobase-containing compound metabolic process
A0006952biological_processdefense response
A0009615biological_processresponse to virus
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0032728biological_processpositive regulation of interferon-beta production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0042742biological_processdefense response to bacterium
A0043231cellular_componentintracellular membrane-bounded organelle
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0070106biological_processinterleukin-27-mediated signaling pathway
A0140374biological_processantiviral innate immune response
A1903487biological_processregulation of lactation
B0000166molecular_functionnucleotide binding
B0001730molecular_function2'-5'-oligoadenylate synthetase activity
B0002376biological_processimmune system process
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006139biological_processnucleobase-containing compound metabolic process
B0006952biological_processdefense response
B0009615biological_processresponse to virus
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0032728biological_processpositive regulation of interferon-beta production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0042742biological_processdefense response to bacterium
B0043231cellular_componentintracellular membrane-bounded organelle
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0070106biological_processinterleukin-27-mediated signaling pathway
B0140374biological_processantiviral innate immune response
B1903487biological_processregulation of lactation
Functional Information from PROSITE/UniProt
site_idPS00832
Number of Residues20
Details25A_SYNTH_1 2'-5'-oligoadenylate synthases signature 1. GSyGRkTvLRgnsDgTLVlF
ChainResidueDetails
AGLY61-PHE80
AGLY395-PHE414

site_idPS00833
Number of Residues11
Details25A_SYNTH_2 2'-5'-oligoadenylate synthases signature 2. RPVILDPvDPT
ChainResidueDetails
AARG288-THR298
AARG632-THR642

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11986302","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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