9GZH
PDGFRA-T674I in complex with covalent ponatinib derivative 19
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-derived growth factor receptor alpha | polymer | 355 | 40437.6 | 1 | UniProt (P16234) Pfam (PF07714) | Homo sapiens (human) | PDGF-R-alpha,PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2 |
| 2 | B (A) | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-~{N}-[4-(propanoylamino)-3-(trifluoromethyl)phenyl]benzamide | non-polymer | 491.5 | 1 | Chemie (A1IRC) | |||
| 3 | C (A) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 550 - 973 (UniProt: P16234)
| PDB | External Database | Details |
|---|---|---|
| Gly 547 | - | expression tag |
| Pro 548 | - | expression tag |
| Gly 549 | - | expression tag |
| Ile 674 | Thr 674 | engineered mutation |
| - | His 697 | deletion |
| - | Pro 698 | deletion |
| - | Glu 699 | deletion |
| - | Lys 700 | deletion |
| - | Pro 701 | deletion |
| - | Lys 702 | deletion |
| - | Lys 703 | deletion |
| - | Glu 704 | deletion |
| - | Leu 705 | deletion |
| - | Asp 706 | deletion |
| - | Ile 707 | deletion |
| - | Phe 708 | deletion |
| - | Gly 709 | deletion |
| - | Leu 710 | deletion |
| - | Asn 711 | deletion |
| - | Pro 712 | deletion |
| - | Ala 713 | deletion |
| - | Asp 714 | deletion |
| - | Glu 715 | deletion |
| - | Ser 716 | deletion |
| - | Thr 717 | deletion |
| - | Arg 718 | deletion |
| - | Ser 719 | deletion |
| - | Tyr 720 | deletion |
| - | Val 721 | deletion |
| - | Ile 722 | deletion |
| - | Leu 723 | deletion |
| - | Ser 724 | deletion |
| - | Phe 725 | deletion |
| - | Glu 726 | deletion |
| - | Asn 727 | deletion |
| - | Asn 728 | deletion |
| - | Gly 729 | deletion |
| - | Asp 730 | deletion |
| - | Tyr 731 | deletion |
| - | Met 732 | deletion |
| - | Asp 733 | deletion |
| - | Met 734 | deletion |
| - | Lys 735 | deletion |
| - | Gln 736 | deletion |
| - | Ala 737 | deletion |
| - | Asp 738 | deletion |
| - | Thr 739 | deletion |
| - | Thr 740 | deletion |
| - | Gln 741 | deletion |
| - | Tyr 742 | deletion |
| - | Val 743 | deletion |
| - | Pro 744 | deletion |
| - | Met 745 | deletion |
| - | Leu 746 | deletion |
| - | Glu 747 | deletion |
| - | Arg 748 | deletion |
| - | Lys 749 | deletion |
| - | Glu 750 | deletion |
| - | Val 751 | deletion |
| - | Ser 752 | deletion |
| - | Lys 753 | deletion |
| - | Tyr 754 | deletion |
| - | Ser 755 | deletion |
| - | Asp 756 | deletion |
| - | Ile 757 | deletion |
| - | Gln 758 | deletion |
| - | Arg 759 | deletion |
| - | Ser 760 | deletion |
| - | Leu 761 | deletion |
| - | Tyr 762 | deletion |
| - | Asp 763 | deletion |
| - | Arg 764 | deletion |
| - | Pro 765 | deletion |
| - | Ala 766 | deletion |
| - | Ser 767 | deletion |
| - | Tyr 768 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40437.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 491.5 | |
| All* | Total formula weight | 40929.1 |
