9GZ1
Beta-cardiac myosin interacting heads motif complexed to mavacamten
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Myosin-7 | polymer | 1145 | 131852.5 | 2 | UniProt (P12883) Pfam (PF02736) Pfam (PF00063) | Homo sapiens (human) | Myosin heavy chain 7,Myosin heavy chain slow isoform,MyHC-slow,Myosin heavy chain,cardiac muscle beta isoform,MyHC-beta |
| 2 | C, D (C, E) | Myosin light chain 1/3, skeletal muscle isoform | polymer | 187 | 20489.3 | 2 | UniProt (P05977) | Mus musculus (house mouse) | MLC1/MLC3,MLC1F/MLC3F,Myosin light chain alkali 1/2,Myosin light chain A1/A2 |
| 3 | E, F (D, F) | Myosin regulatory light chain 11 | polymer | 168 | 18847.2 | 2 | UniProt (P97457) Pfam (PF13405) | Mus musculus (house mouse) | Fast skeletal myosin light chain 2,MLC2F,Myosin light chain 11,Myosin regulatory light chain 2,skeletal muscle isoform |
| 4 | G, K, O, P (A, B, D, F) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | H, L (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 6 | I, M (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | J, N (A, B) | Mavacamten | non-polymer | 273.3 | 2 | Chemie (XB2) |
Sequence modifications
A, B: 2 - 1138 (UniProt: P12883)
| PDB | External Database | Details |
|---|---|---|
| Ser 1124 | Ala 1124 | variant |
| Asp 1139 | - | expression tag |
| Tyr 1140 | - | expression tag |
| Lys 1141 | - | expression tag |
| Asp 1142 | - | expression tag |
| Asp 1143 | - | expression tag |
| Asp 1144 | - | expression tag |
| Asp 1145 | - | expression tag |
| Lys 1146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 342378.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1688.2 | |
| All* | Total formula weight | 344066.3 |
