9GZ1

Beta-cardiac myosin interacting heads motif complexed to mavacamten

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
A	0051015	molecular_function	actin filament binding
B	0003774	molecular_function	cytoskeletal motor activity
B	0005524	molecular_function	ATP binding
B	0016459	cellular_component	myosin complex
B	0051015	molecular_function	actin filament binding
C	0000146	molecular_function	microfilament motor activity
C	0003774	molecular_function	cytoskeletal motor activity
C	0005509	molecular_function	calcium ion binding
C	0006936	biological_process	muscle contraction
C	0008307	molecular_function	structural constituent of muscle
C	0016459	cellular_component	myosin complex
C	0016460	cellular_component	myosin II complex
C	0016461	cellular_component	unconventional myosin complex
C	0030016	cellular_component	myofibril
C	0030049	biological_process	muscle filament sliding
C	0043292	cellular_component	contractile muscle fiber
C	0060048	biological_process	cardiac muscle contraction
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0006936	biological_process	muscle contraction
D	0007519	biological_process	skeletal muscle tissue development
D	0008307	molecular_function	structural constituent of muscle
D	0016459	cellular_component	myosin complex
D	0046872	molecular_function	metal ion binding
E	0000146	molecular_function	microfilament motor activity
E	0003774	molecular_function	cytoskeletal motor activity
E	0005509	molecular_function	calcium ion binding
E	0006936	biological_process	muscle contraction
E	0008307	molecular_function	structural constituent of muscle
E	0016459	cellular_component	myosin complex
E	0016460	cellular_component	myosin II complex
E	0016461	cellular_component	unconventional myosin complex
E	0030016	cellular_component	myofibril
E	0030049	biological_process	muscle filament sliding
E	0043292	cellular_component	contractile muscle fiber
E	0060048	biological_process	cardiac muscle contraction
F	0005509	molecular_function	calcium ion binding
F	0005737	cellular_component	cytoplasm
F	0006936	biological_process	muscle contraction
F	0007519	biological_process	skeletal muscle tissue development
F	0008307	molecular_function	structural constituent of muscle
F	0016459	cellular_component	myosin complex
F	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGIIDkeDL

Chain	Residue	Details
D	ASP37-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Domain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	64
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04466","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04466","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---