9GMO
eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 28S rRNA | polymer | 5064 | 1639262.3 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | 5S rRNA | polymer | 119 | 38346.7 | 1 | GenBank (23898) | Homo sapiens (human) | |
| 3 | C (C) | 5.8S rRNA | polymer | 157 | 50463.8 | 1 | GenBank (555853) | Homo sapiens (human) | |
| 4 | D (D) | 60S ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (human) | Large ribosomal subunit protein uL2 |
| 5 | E (E) | 60S ribosomal protein L3 | polymer | 403 | 46211.1 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 6 | F (F) | 60S ribosomal protein L4 | polymer | 427 | 47804.6 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 7 | G (G) | 60S ribosomal protein L5 | polymer | 297 | 34426.8 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (human) | Large ribosomal subunit protein uL18 |
| 8 | H (H) | Large ribosomal subunit protein eL6 | polymer | 288 | 32810.2 | 1 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (human) | 60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 9 | I (I) | 60S ribosomal protein L13a | polymer | 203 | 23633.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 10 | J (J) | 60S ribosomal protein L17 | polymer | 184 | 21443.2 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 11 | K (K) | 60S ribosomal protein L18 | polymer | 188 | 21687.7 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | Large ribosomal subunit protein eL18 |
| 12 | L (L) | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | UniProt (P84098) Pfam (PF01280) Pfam (PF25476) | Homo sapiens (human) | Large ribosomal subunit protein eL19 |
| 13 | M (M) | 60S ribosomal protein L18a | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | Large ribosomal subunit protein eL20 |
| 14 | N (N) | 60S ribosomal protein L21 | polymer | 160 | 18610.0 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | Large ribosomal subunit protein eL21 |
| 15 | O (O) | 60S ribosomal protein L22 | polymer | 128 | 14813.0 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 16 | P (P) | 60S ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L17,Large ribosomal subunit protein uL14 |
| 17 | Q (Q) | 60S ribosomal protein L24 | polymer | 157 | 17825.1 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (human) | 60S ribosomal protein L30,Large ribosomal subunit protein eL24 |
| 18 | R (R) | 60S ribosomal protein L23a | polymer | 156 | 17740.2 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (human) | Large ribosomal subunit protein uL23 |
| 19 | S (S) | Large ribosomal subunit protein uL24 | polymer | 145 | 17303.4 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | 60S ribosomal protein L26 |
| 20 | T (T) | 60S ribosomal protein L27 | polymer | 136 | 15835.8 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | Large ribosomal subunit protein eL27 |
| 21 | U (U) | 60S ribosomal protein L27a | polymer | 148 | 16604.5 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | Large ribosomal subunit protein uL15 |
| 22 | V (V) | 60S ribosomal protein L29 | polymer | 159 | 17804.3 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (human) | Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29 |
| 23 | W (W) | 60S ribosomal protein L30 | polymer | 115 | 12805.1 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL30 |
| 24 | X (X) | 60S ribosomal protein L31 | polymer | 125 | 14494.9 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | Large ribosomal subunit protein eL31 |
| 25 | Y (Y) | 60S ribosomal protein L32 | polymer | 135 | 15898.9 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | Large ribosomal subunit protein eL32 |
| 26 | Z (Z) | 60S ribosomal protein L35a | polymer | 110 | 12564.7 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 27 | AA (a) | 60S ribosomal protein L34 | polymer | 117 | 13326.1 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | Large ribosomal subunit protein eL34 |
| 28 | BA (b) | 60S ribosomal protein L35 | polymer | 123 | 14593.6 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | Large ribosomal subunit protein uL29 |
| 29 | CA (c) | 60S ribosomal protein L36 | polymer | 105 | 12290.9 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | Large ribosomal subunit protein eL36 |
| 30 | DA (d) | 60S ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | G1.16,Large ribosomal subunit protein eL37 |
| 31 | EA (e) | 60S ribosomal protein L38 | polymer | 70 | 8238.9 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | Large ribosomal subunit protein eL38 |
| 32 | FA (f) | 60S ribosomal protein L39 | polymer | 51 | 6426.8 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | Large ribosomal subunit protein eL39 |
| 33 | GA (g) | Ubiquitin-60S ribosomal protein L40 | polymer | 128 | 14758.4 | 1 | UniProt (P62987) Pfam (PF00240) Pfam (PF01020) | Homo sapiens (human) | CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 34 | HA (h) | Eukaryotic translation initiation factor 6 | polymer | 245 | 26620.0 | 1 | UniProt (P56537) Pfam (PF01912) | Homo sapiens (human) | eIF-6,B(2)GCN homolog,B4 integrin interactor,CAB,p27(BBP) |
| 35 | IA (i) | 60S ribosomal protein L36a | polymer | 106 | 12477.0 | 1 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (human) | 60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42 |
| 36 | JA (j) | 60S ribosomal protein L37a | polymer | 92 | 10299.4 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | Large ribosomal subunit protein eL43 |
| 37 | KA (k) | 60S ribosomal protein L28 | polymer | 137 | 15784.6 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | Large ribosomal subunit protein eL28 |
| 38 | LA (l) | 60S ribosomal protein L15 | polymer | 204 | 24207.3 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | Large ribosomal subunit protein eL15 |
| 39 | MA (m) | Large ribosomal subunit protein uL30 | polymer | 248 | 29291.0 | 1 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (human) | 60S ribosomal protein L7 |
| 40 | NA (n) | 60S ribosomal protein L7a | polymer | 266 | 30061.8 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 41 | OA (o) | 60S ribosomal protein L9 | polymer | 192 | 21899.5 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | Large ribosomal subunit protein uL6 |
| 42 | PA (p) | Large ribosomal subunit protein uL16 | polymer | 204 | 23610.8 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (human) | 60S ribosomal protein L10,Laminin receptor homolog,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 43 | QA (q) | 60S ribosomal protein L11 | polymer | 178 | 20288.5 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 44 | RA (r) | 60S ribosomal protein L13 | polymer | 211 | 24321.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 45 | SA (s) | 60S ribosomal protein L14 | polymer | 215 | 23485.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 46 | TA (0) | Cytoplasmic 60S subunit biogenesis factor ZNF622 | polymer | 477 | 54357.1 | 1 | UniProt (Q969S3) Pfam (PF12171) Pfam (PF12756) | Homo sapiens (human) | Zinc finger protein 622,Zinc finger-like protein 9 |
| 47 | AB, AC, AD, AE, AF... (A, L, P, U, B...) | MAGNESIUM ION | non-polymer | 24.3 | 227 | Chemie (MG) PubChem (888) | |||
| 48 | AJ, AK, AL, AM, AN... (A, N, V, Y, Z...) | POTASSIUM ION | non-polymer | 39.1 | 155 | Chemie (K) PubChem (813) | |||
| 49 | DO, EO (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 50 | OO (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 51 | BP (M) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) | |||
| 52 | IP, JP, LP, OP, PP (a, d, g, i, j) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 53 | VP, WP (A, G) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
p: 1 - 204 (UniProt: P27635)
| PDB | External Database | Details |
|---|---|---|
| - | Met 102 | deletion |
| - | Leu 103 | deletion |
| - | Ser 104 | deletion |
| - | Cys 105 | deletion |
| - | Ala 106 | deletion |
| - | Gly 107 | deletion |
| - | Ala 108 | deletion |
| - | Asp 109 | deletion |
| - | Arg 110 | deletion |
| - | Leu 111 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 46 |
| Total formula weight | 2633164.2 | |
| Non-Polymers* | Number of molecules | 391 |
| Total formula weight | 12711.9 | |
| All* | Total formula weight | 2645876.1 |
