9GGN
Cryo-EM structure of KBTBD4 WT-HDAC2 2:2 complex mediated by molecular glue UM171
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform 1 of Kelch repeat and BTB domain-containing protein 4 | polymer | 518 | 58208.7 | 2 | UniProt (Q9NVX7) Pfam (PF00651) Pfam (PF07707) Pfam (PF07646) | Homo sapiens (human) | BTB and kelch domain-containing protein 4 |
| 2 | B, D (B, D) | Histone deacetylase 2 | polymer | 488 | 55443.2 | 2 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (human) | HD2,Protein deacylase HDAC2 |
| 3 | E, G (B, D) | (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine | non-polymer | 453.5 | 2 | Chemie (A1ACV) | |||
| 4 | F, H (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 227303.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1037.9 | |
| All* | Total formula weight | 228341.7 |
