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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9GE2

Structure of GPR55 in complex with G13 and synthetic agonist ML184

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein subunit alpha-13polymer23026574.41UniProt (P04899)
UniProt (Q14344)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein,G alpha-13,G-protein subunit alpha-13
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35839418.11UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(F)		Single-chain variable fragment ScFv16polymer25327068.21Mus musculus (mouse)
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer808506.81UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(R)		Green fluorescent protein,G-protein coupled receptor 55,G-protein coupled receptor 55polymer65073124.81UniProt (Q9Y2T6)
Pfam (PF00001)		Aequorea victoria (Water jellyfish)
6F
(X)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
7G
(R)		3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamidenon-polymer470.61Chemie (A1IKH)
PubChem (2440433)
8H
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
9I, J, K
(A, B, R)		waterwater18.014Chemie (HOH)
Sequence modifications
A: 1 - 15 (UniProt: P04899)
PDBExternal DatabaseDetails
Ser 3Cys 3engineered mutation
A: 16 - 58 (UniProt: Q14344)
PDBExternal DatabaseDetails
Asp 42Gly 57engineered mutation
Asn 43Glu 58engineered mutation
A: 66 - 230 (UniProt: Q14344)
PDBExternal DatabaseDetails
Gly 59-linker
Ser 60-linker
Gly 61-linker
Gly 62-linker
Ser 63-linker
Gly 64-linker
Gly 65-linker
Asp 111Ser 248engineered mutation
Asp 114Glu 251engineered mutation
-Asp 253deletion
-Gln 254deletion
-Val 255deletion
-Leu 256deletion
-Met 257deletion
-Glu 258deletion
-Asp 259deletion
-Arg 260deletion
-Leu 261deletion
-Thr 262deletion
Asp 124Ile 271engineered mutation
Ala 208Ile 355engineered mutation
Ile 211Val 358engineered mutation
B: 20 - 358 (UniProt: P62873)
PDBExternal DatabaseDetails
Met 1-initiating methionine
His 2-expression tag
His 3-expression tag
His 4-expression tag
His 5-expression tag
His 6-expression tag
His 7-expression tag
Leu 8-expression tag
Glu 9-expression tag
Val 10-expression tag
Leu 11-expression tag
Phe 12-expression tag
Gln 13-expression tag
Gly 14-expression tag
Pro 15-expression tag
Gly 16-expression tag
Ser 17-expression tag
Ser 18-expression tag
Gly 19-expression tag
G: 1 - 71 (UniProt: P59768)
PDBExternal DatabaseDetails
Gly 72-expression tag
Ser 73-expression tag
Ala 74-expression tag
Gly 75-expression tag
Ser 76-expression tag
Ala 77-expression tag
Gly 78-expression tag
Ser 79-expression tag
Ala 80-expression tag
R: -280 - 0 (PDB: 9GE2)
R: 1 - 319 (UniProt: Q9Y2T6)
PDBExternal DatabaseDetails
Ala 320-expression tag
Gly 321-expression tag
Ser 322-expression tag
Gly 323-expression tag
Ala 324-expression tag
Gly 325-expression tag
Ser 326-expression tag
Ala 327-expression tag
Trp 328-expression tag
Ser 329-expression tag
His 330-expression tag
Pro 331-expression tag
Gln 332-expression tag
Phe 333-expression tag
Glu 334-expression tag
Lys 335-expression tag
Gly 336-expression tag
Gly 337-expression tag
Gly 338-expression tag
Ser 339-expression tag
Gly 340-expression tag
Gly 341-expression tag
Gly 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Ser 346-expression tag
Ala 347-expression tag
Trp 348-expression tag
Ser 349-expression tag
His 350-expression tag
Pro 351-expression tag
Gln 352-expression tag
Phe 353-expression tag
Glu 354-expression tag
Lys 355-expression tag
Gly 356-expression tag
Ala 357-expression tag
Gly 358-expression tag
Ser 359-expression tag
His 360-expression tag
His 361-expression tag
His 362-expression tag
His 363-expression tag
His 364-expression tag
His 365-expression tag
His 366-expression tag
His 367-expression tag
His 368-expression tag
His 369-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight174692.3
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules2
Total formula weight857.3
All*Total formula weight175974.0
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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