9GC7
Mineralocorticoid receptor in complex with acylurea antagonists.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mineralocorticoid receptor | polymer | 305 | 34832.8 | 1 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR,Nuclear receptor subfamily 3 group C member 2 |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 12 | 1429.6 | 1 | UniProt (Q15788) | Homo sapiens (human) | NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 3 | C (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 4 | D (A) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 5 | E (A) | (2S)-N-aminocarbonyl-2-[(4-cyano-6-cyclopropyl-cyclohexa-1,2,3,5-tetraen-1-yl)amino]propanamide | non-polymer | 270.3 | 1 | Chemie (A1IJ6) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A: 735 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Met 713 | - | initiating methionine |
| His 714 | - | expression tag |
| Asn 715 | - | expression tag |
| His 716 | - | expression tag |
| Asn 717 | - | expression tag |
| His 718 | - | expression tag |
| Asn 719 | - | expression tag |
| His 720 | - | expression tag |
| Asn 721 | - | expression tag |
| His 722 | - | expression tag |
| Asn 723 | - | expression tag |
| His 724 | - | expression tag |
| Asn 725 | - | expression tag |
| Gly 726 | - | expression tag |
| Gly 727 | - | expression tag |
| Glu 728 | - | expression tag |
| Asn 729 | - | expression tag |
| Leu 730 | - | expression tag |
| Tyr 731 | - | expression tag |
| Phe 732 | - | expression tag |
| Gln 733 | - | expression tag |
| Gly 734 | - | expression tag |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
| Ser 910 | Cys 910 | engineered mutation |
| Gly 985 | - | expression tag |
| Gly 986 | - | expression tag |
| Ser 987 | - | expression tag |
| Leu 988 | - | expression tag |
| Val 989 | - | expression tag |
| Pro 990 | - | expression tag |
| Arg 991 | - | expression tag |
| Gly 992 | - | expression tag |
| Ser 993 | - | expression tag |
| Gly 994 | - | expression tag |
| Gly 995 | - | expression tag |
| Gly 996 | - | expression tag |
| Ser 997 | - | expression tag |
| Gly 998 | - | expression tag |
| Gly 999 | - | expression tag |
| Ser 1000 | - | expression tag |
| Gly 1001 | - | expression tag |
| Gly 1002 | - | expression tag |
| Pro 1003 | - | expression tag |
| Gln 1004 | - | expression tag |
| Ala 1005 | - | expression tag |
| Gln 1006 | - | expression tag |
| Gln 1007 | - | expression tag |
| Lys 1008 | - | expression tag |
| Ser 1009 | - | expression tag |
| Leu 1010 | - | expression tag |
| Leu 1011 | - | expression tag |
| Gln 1012 | - | expression tag |
| Gln 1013 | - | expression tag |
| Leu 1014 | - | expression tag |
| Leu 1015 | - | expression tag |
| Thr 1016 | - | expression tag |
| Glu 1017 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36262.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 595.8 | |
| All* | Total formula weight | 36858.1 |
