9GBF
X-RAY structure of PHDvC5HCH tandem domain of NSD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase NSD2 | polymer | 103 | 11441.9 | 2 | UniProt (O96028) Pfam (PF23011) Pfam (PF17982) | Homo sapiens (human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
| 2 | C, D, E, F, I... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, M (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | N (B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B: 1229 - 1331 (UniProt: O96028)
| PDB | External Database | Details |
|---|---|---|
| Ser 1324 | Cys 1324 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22883.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 913.7 | |
| All* | Total formula weight | 23797.6 |
