9FZA
TEAD1/YAP in complex with a reversible inhibitor N-[(4-phenoxyphenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Transcriptional enhancer factor TEF-1 | polymer | 220 | 25461.0 | 2 | UniProt (P28347) Pfam (PF17725) | Homo sapiens (human) | NTEF-1,Protein GT-IIC,TEA domain family member 1,TEAD-1,Transcription factor 13,TCF-13 |
| 2 | B, D (B, D) | Transcriptional coactivator YAP1 | polymer | 60 | 6720.6 | 2 | UniProt (P46937) Pfam (PF15238) | Homo sapiens (human) | Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog |
| 3 | E, G (A, C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | F, H (A, C) | ~{N}-[(4-phenoxyphenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide | non-polymer | 343.4 | 2 | Chemie (A1IHH) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, C: 207 - 426 (UniProt: P28347)
| PDB | External Database | Details |
|---|---|---|
| Pro 208 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64363.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 757.7 | |
| All* | Total formula weight | 65120.9 |
