9FSH
Crystal structure of the HECT domain of Smurf 2 in complex with inhibitor 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase SMURF2 | polymer | 499 | 58203.9 | 1 | UniProt (Q9HAU4) Pfam (PF00397) Pfam (PF00632) | Homo sapiens (human) | hSMURF2,HECT-type E3 ubiquitin transferase SMURF2,SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2 |
| 2 | B (A) | ethyl 5-[1,3-benzodioxol-5-ylmethyl(ethyl)carbamoyl]-2,4-dimethyl-1~{H}-pyrrole-3-carboxylate | non-polymer | 372.4 | 1 | Chemie (TJQ) | |||
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 251 - 748 (UniProt: Q9HAU4)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 58203.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.4 | |
| All* | Total formula weight | 58671.3 |
